Pregnancy joy for lupus sufferer, 29, who was told she could never carry children

At just 20 years old, then-law student Paula Birch Bilingsley was told she had less than 10 years to live and was infertile. Ten years later, she is healthy, thriving, and has two children.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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AbstractIntroductionWe sought to characterize changes in healthcare spending associated with the onset of 22 endometriosis-related comorbidities.MethodsWomen aged 18 –49 years with endometriosis (N = 180,278) were extracted from 2006–2015 de-identified Clinformatics® DataMart claims data. For 22 comorbidities, comorbidity patients were identified on the basis of having a first comorbidity diagnosis after their initial endometriosis diagnosis. Controls were identified on the basis of having no comorbidity diagnosis and were matched 1:1 to comorbidity patients on demographics and baseline spend...
Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research
AbstractPurpose of ReviewThis review focuses on the relationship between anti-phospholipid antibodies (aPL) and female infertility by addressing three key questions: (i) how can aPL induce women ’s infertility?; (ii) are aPL more prevalent among infertile than fertile women?; (iii) do aPL-positive women display reduced fertility?Recent FindingsAccording to experimental data, aPL impair female fertility interfering with endometrial decidualization thus with implantation. Some aPL tests are more frequently detected among infertile women compared to controls; the association between aPL and assisted reproduction techniq...
Source: Current Rheumatology Reports - Category: Rheumatology Source Type: research
Renal disease in systemic lupus erythematosus (SLE) carries significant morbidity and mortality. Cyclophosphamide (CYC)- and mycophenolate mofetil (MMF)–based induction regimens are not ideal in terms of efficacy and toxicity. The adverse effects of CYC, such as infection risk, infertility, urotoxicity and oncogenicity, limit its use in lupus nephritis. Although MMF is non-inferior to CYC as induction therapy and has reduced gonadal toxicity and oncogenic potential, meta-analyses of clinical trials do not show a lower rate of infective and gastrointestinal complications. Tacrolimus (TAC) has recently been shown to ha...
Source: Nephrology Dialysis Transplantation - Category: Urology & Nephrology Authors: Tags: POLAR VIEWS IN NEPHROLOGY Source Type: research
AbstractOn average, 10  % of infertile couples have unexplained infertility. Auto-immune disease (systemic lupus erythematosus, anti-phospholipid syndrome) accounts for a part of these cases. In the last 20 years, aspecific auto-immunity, defined as positivity of auto-antibodies in blood sample without clinical or biolo gical criteria for defined diseases, has been evoked in a subpopulation of infertile women. A systematic review was performed (PUBMED) using the MESH search terms “infertility” and “auto-immunity” or “reproductive technique” or “assisted reproduction&rdquo...
Source: Clinical Reviews in Allergy and Immunology - Category: Allergy & Immunology Source Type: research
Discussion Klinefelter syndrome (KS) is a common genetic abnormaly with a prevalence of 1 in ~650 male births. It was first described in 1942 by Dr. Harry Klinefelter. It is associated with at least one extra X chromosome with the most common karyotype (~80% of patients) being 47 XXY. Other karyotypes are seen along with mosaicism. It is believed that although it is very prevalent, only about 25-33% of people with KS are identified. About 10% are identified before puberty with the rest usually identified because of hypogonadism and tall stature especially in teenage years or due to infertility in adulthood. KS is diagnosed...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Anti-phospholipid antibodies (aPL) are autoantibodies that are associated with thrombosis and a range of pregnancy complications including recurrent pregnancy loss and pre-eclampsia. The three clinically relevant, well-characterized aPL are anti-cardiolipin antibodies, lupus anticoagulant and anti-beta-2-glycoprotein I (β2GPI) antibodies. aPL do not bind directly to phospholipids but instead bind to a plasma-binding ‘cofactor’. The most extensively studied cofactor is β2GPI, whose role in pregnancy is not fully elucidated. Although the pathogenicity of aPL in recurrent pregnancy loss is well establish...
Source: Reproduction - Category: Reproduction Medicine Authors: Tags: Reviews Source Type: research
Authors: Silva CA, Aikawa NE, Pereira RM, Campos LM Abstract Childhood-onset systemic lupus erythematosus (cSLE) is a chronic inflammatory and autoimmune disease that may involve various organs and systems. This narrative review focuses on the recent evidence relating to cSLE management. The general management considerations of cSLE patients require the use of validated classification criteria, disease and health-related quality of life tools evaluation, as well as assessments of lupus nephritis biomarkers and cSLE quality indicators. The drug treatment for cSLE patients includes general supportive care and immunos...
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research
Abstract: Women are far more likely than men to have a diagnosis of systemic lupus erythematosus (SLE), with a peak incidence during the childbearing years. Contraceptive methods and pregnancy can both adversely affect the health of women with SLE, thus careful planning and interventions are necessary to help women manage their reproductive health choices. Women with SLE may experience infertility, difficulties conceiving and maintaining pregnancy, and ultimately have less children than they had planned. Although poor health status may account for some of this disparity, inadequate counseling and management by members of t...
Source: MCN: The American Journal of Maternal Child Nursing - Category: Nursing Tags: Feature: CE Connection Source Type: research
Systemic lupus erythematosus (SLE) is a chronic autoimmune systemic disease that mainly affects women of reproductive age. Emerging data from recent molecular studies show us that estrogen hormone plays a central role in the development of this disease. By acting via its cognate receptors ERα and ERβ expressed on immune cells, estrogen can modulate immune function in both the innate and adaptive immune responses. Interestingly, estrogen may also evoke autoimmune responses after binding to B lymphocytes leading to the generation of high-affinity autoantibodies and proinflammatory cytokines (so-called estrogen-ind...
Source: Obstetrical and Gynecological Survey - Category: OBGYN Tags: CME Articles Source Type: research
Publication date: Available online 30 December 2014 Source:Autoimmunity Reviews Author(s): Monika Østensen , Laura Andreoli , Antonio Brucato , Irene Cetin , Christina Chambers , Megan Clowse , Nathalie Costedoat-Chalumeau , Maurizio Cutolo , Radboud Dolhain , M. Fenstad , Frauke Förger , Marie Wahren-Herlenius , Guillermo Ruiz-Irastorza , Hege Koksvik , Catherine Nelson-Piercy , Yehuda Shoenfeld , Angela Tincani , Peter M. Villiger , Marianne Wallenius , Michael von Wolff Throughout the last decade, increasing awareness has been raised on issues related to reproduction in rheumatic diseases including basic r...
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
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