Effects of different doses of curcumin on testicular histopathology, apoptosis, and reproductive organs weight index in mice d -galactose-induced aging model

AbstractDue to the value of aging and its effect on body organs, it is necessary to study the factors that can have protective effects on this process. Curcumin is the active ingredient ofCurcuma longa Turmeric, which has a strong antioxidant effect. We evaluated the curcumin treatment on testicular histopathology, apoptosis, and reproductive organs index in a mouse model of aging. Forty-eight mice divided into control, sham,d-galactose, and curcumin 1 to 3 groups. Thed-galactose group was administered intraperitoneally 300  mg/kgd-galactose for 6  weeks. The curcumin 1 to 3 groups receivedd-galactose plus 25, 50, and 100  mg/kg of curcumin, respectively for 14 days. Then, testicular histopathology, apoptosis, and reproductive organs index were investigated after 6 weeks. The SPSS software was used for data analysis. Tunnel-positive cells in thed-galactose group were remarkably higher than the control group (p 
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research

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