Secondary Amyloidosis associated with Heroin use and Recurrent Infections – A Case Report

Publication date: Available online 22 November 2018Source: Annals of Medicine and SurgeryAuthor(s): Deepthi ManiAbstractA 49-year-old lady with history of polysubstance use disorder, recurrent cutaneous abscesses, spinal diskitis and septic thrombophlebitis presented to the emergency room with complaints of intermittent fevers, worsening right hip pain and bilateral lower extremity edema. A month before the presentation, she had left another hospital against medical advice after being diagnosed with Methicillin-resistant Staphylococcus aureus bacteremia and right hip septic arthritis. Post discharge, she was off antibiotics, but continued heroin and methamphetamine use. On admission, she had right hip chronic osteomyelitis and was also in acute renal failure with evidence of nephrotic range proteinuria. Her renal biopsy subsequently revealed acute tubular necrosis and secondary (AA) amyloidosis with the classic apple green birefringence and positive immunohistochemical stain for serum amyloid A protein. Secondary amyloidosis, where there is deposition of fibrils composed of fragments of the acute phase reactant - serum amyloid A protein, often complicates chronic diseases with ongoing or recurring inflammation like spondyloarthropathies, inflammatory bowel disease and heredofamilial periodic fever syndromes.Epidemiological studies now indicate that chronic inflammation as noted in illicit drug users, especially heroin users is on the rise as the etiology for AA amyloidosis in...
Source: Annals of Medicine and Surgery - Category: General Medicine Source Type: research

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Publication date: Available online 16 July 2019Source: Journal of Contextual Behavioral ScienceAuthor(s): Kitty Kioskli, Kirsty Winkley, Lance M. McCrackenAbstractPainful diabetic neuropathy (PDN) is a distressing and disabling condition. There is, surprisingly, relatively little research into the role of psychological variables related to PDN. The aim of this study was to investigate the association between psychological flexibility, daily functioning, and distress in people with PDN. This cross-sectional study included 225 participants who were recruited from hospital services and online. In correlation analyses, accepta...
Source: Journal of Contextual Behavioral Science - Category: Psychiatry & Psychology Source Type: research
This study addressed an original isotopically-paired chiral derivatization approach for UPLC-MS/MS quantification of 2-HG metabolic panel. To achieve better chromatographic separation, N-(p-toluenesulfonyl)-L-phenylalanyl chloride (TSPC) was utilized as an optical resolving reagent to form diastereomers. For accurate quantitation, an 18O2-labeled-TSPC reagent was designed and readily synthesized to produce one-to-one internal standards. The developed approach enabled an accurate quantification of 13 immunometabolites in 2-HG metabolic panel with good linearity (R2 > 0.99) and high sensitivity (0.5-120 fmol for LLO...
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research
The FDA has granted marketing clearance for a low-level laser device for the treatment of"whole body" musculoskeletal pain, the manufacturer has announced.FDA Approvals
Source: Medscape FamilyMedicine Headlines - Category: Primary Care Tags: Neurology & Neurosurgery News Alert Source Type: news
Conclusion: Our meta-analysis results revealed higher cardiovascular risk in OA patients. This highlights the importance of cardiovascular risk factor management in OA.
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research
Publication date: Available online 2 July 2019Source: Joint Bone SpineAuthor(s): Johann BeaudreuilAbstractIntradiskal steroid injections were first used 70 years ago. The initial failure of this treatment method can be ascribed to the absence of preclinical studies and of well-defined criteria for patient selection. Intradiskal calcifications were reported after triamcinolone hexacetonide or cortivazol injections, and proof of clinical benefits remained elusive. The concept of active degenerative disk disease (DDD) then emerged, and cases of incapacitating chronic low back pain with Modic I endplate changes were reported, ...
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research
Healthcare-associated infections (HAIs) continue to be an ongoing threat to patients. “Despite the best care, patients get infections,” Brian Gross, business lead, genomics for infectious disease at Philips, told MD+DI. Because they are “technically avoidable, there’s pressure on hospitals to drive their numbers down.” Healthcare system professionals have struggled with two main problems when trying to identify and act on infection risks, Gross explained. “The problem is two-fold. First, because of current tools, all...
Source: MDDI - Category: Medical Devices Authors: Tags: Software Source Type: news
The World Health Organization issued the order as the ebola virus has infected more than 2,500 people and killed more than 1,660.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Ebola Virus World Health Organization United Nations Congo, Democratic Republic of (Congo-Kinshasa) Tedros Adhanom Ghebreyesus Medicine and Health Epidemics your-feed-healthcare Source Type: news
Publication date: Available online 16 July 2019Source: Comparative Immunology, Microbiology and Infectious DiseasesAuthor(s): Hanna R.C. Shoen, Sasha J. Rose, Stephen A. Ramsey, Helio de Morais, Luiz E. BermudezAbstractRecords of all Diagnostic laboratory submissions from 2012 –2015 were examined and subjected to analysis according to species, location of infection, species of bacteria, and antibiotic resistance/susceptibility. A total of 23.8% of all culture isolates were Staphylococcus sp. Of those Staphylococcus, 43% were isolated from surgical site infections.Staphylococcus pseudintermedius accounted for approxim...
Source: Comparative Immunology, Microbiology and Infectious Diseases - Category: Infectious Diseases Source Type: research
ConclusionsOur findings underscore the need to optimize the patient experience with placement, ongoing use, and removal of urinary catheters and PICCs.Graphical Abstract
Source: American Journal of Infection Control - Category: Infectious Diseases Source Type: research
Publication date: Available online 16 July 2019Source: American Journal of Infection ControlAuthor(s): Shanice Cheatham, Dipendra Thapaliya, Mohammed Taha, Katherine Milliken, Mark R. Dalman, Jhalka Kadariya, Dylan Grenier, Tara C. SmithBackgroundMethicillin-resistant Staphylococcus aureus (MRSA) is common in medical institutions. We sought to examine the prevalence of S aureus on environmental surfaces in nursing homes and to obtain molecular information on contaminating strains.MethodsA total of 259 environmental samples were collected from 7 different nursing homes in Northeast Ohio (NEO), from suburban, urban, and rura...
Source: American Journal of Infection Control - Category: Infectious Diseases Source Type: research
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