Novel Roles for SUMOylation in Cellular Plasticity.

Novel Roles for SUMOylation in Cellular Plasticity.
Trends Cell Biol. 2018 Dec;28(12):971-973
Authors: Di Stefano B, Hochedlinger K
Abstract
Cell fate transitions involve rapid changes in gene expression patterns, yet the role of post-translational modifications in these processes remains underexplored. A recent study identifies SUMOylation as a guardian of cell identity that acts during differentiation and reprogramming by reinforcing active enhancers and maintaining silenced heterochromatin in a context-specific manner.
PMID: 30463679 [PubMed - in process]

Source: Trends in Cell Biology - November 23, 2018 Category: Cytology Authors: Di Stefano B, Hochedlinger K Tags: Trends Cell Biol Source Type: research