Inhibition of microRNA-376b Protects Against Renal Interstitial Fibrosis via Inducing Macrophage Autophagy by Upregulating Atg5 in Mice with Chronic Kidney Disease

Conclusion: miR-376b downregulation promotes macrophage autophagy to relieve RIF by negatively regulating Atg5 in mice with CKD. Thus, miR-376b might represent a potential focus of future investigations on treatments for CKD.Kidney Blood Press Res 2018;43:1749 –1764
Source: Kidney and Blood Pressure Research - Category: Urology & Nephrology Source Type: research