Bone fragility after spinal cord injury: reductions in stiffness and bone mineral at the distal femur and proximal tibia as a function of time

ConclusionsAfter SCI, individuals experienced rapid and profound reductions in bone stiffness and bone mineral at the knee. FE models predicted similar reductions to axial and torsional stiffness, suggesting that both failure modes may be clinically relevant. Importantly, CT-derived measures of bone mineral alone underpredicted the impacts of SCI, compared to FE-derived measures of stiffness.Trial registrationClinicalTrials.gov (NCT01225055, NCT02325414)

http://link.springer.com/10.1007/s00198-018-4733-0

Source: Osteoporosis International - November 23, 2018 Category: Orthopaedics Source Type: research