Healthcare resource utilization and costs associated with incremental systemic corticosteroid exposure in asthma

ConclusionsOver the long term, adverse outcomes associated with SCS initiation were relatively frequent and costly, with a positive dosage –response relationship with SCS exposure.
Source: Allergy - Category: Allergy & Immunology Authors: Tags: ORIGINAL ARTICLE Source Type: research

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We thank Huisstede et  al1 for their interest in our publication and their comments. Like the authors we agree wholeheartedly that weight reduction is key to improving asthma control and quality of life in obese patients, and that bariatric surgery is one treatment option to help achieve this. However, access to bariatr ic surgery varies between countries. In the United Kingdom, this option is available only for those patients who have a body mass index (BMI) range of 35 to 40 together with additional medical problems such as type 2 diabetes or high blood pressure proven to be improved by marked weight loss, or a B MI of more than 40.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Correspondence Source Type: research
Conclusions: Asthma was associated to bronchiectasis in 76% of the patients but it was estimated as etiology in only every fifth patient. However, retrospectively it is difficult to exclude asthma as a background cause in many cases with recurrent asthma like symptoms and respiratory infections. Nevertheless, in one fifth of the patients no identifiable cause was found. None of the patients had had tuberculosis. Lung function test results were well preserved and in 66% bronchiectasis was restricted to one-three lobes.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Epidemiology Source Type: research
Zein is a protein in corn (“maize” outside the U.S.) that, if held side-by-side against the gliadin protein of wheat, rye, or barley, overlaps substantially in structure (i.e., amino acid sequence). In other words, the zein protein of corn resembles the gliadin protein of other grains—not identical but with overlapping similarities in structure. This should come as no surprise, as corn and other grains share evolutionary history as grasses, not to mention ongoing exchange of genetic material over eons, given the impressive promiscuity of grasses and their ability to share and combine genetic material. (Re...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates grain-free grains Inflammation wheat belly Source Type: blogs
Type 2 diabetes and asthma share a common pathophysiology: “chronic inflammation.” However, it is unclear whether patients with type 2 diabetes are at increased risk of asthma.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research
When I was in South Africa last year, I met a revolutionary winemaker… His wine was completely organic. It had no toxins, and it contained powerful antioxidant properties. It was infused with a local herb called rooibos, also known as “red bush.” You may have seen rooibos tea on supermarket shelves. I immediately knew this wine should be made widely available in America — and I’m still hopeful a distributor will bring it here. I enjoy a nice glass of red wine from time to time, but the trouble with most of the wines sold in America is that they’re loaded with dangerous chemicals. Winema...
Source: Al Sears, MD Natural Remedies - Category: Complementary Medicine Authors: Tags: Health additives natural organic Sulfites wine Source Type: news
Conclusions: Peroral arsenic has little effect on local airway immune responses to bacteria but compromises respiratory epithelial barrier integrity, increasing systemic translocation of inhaled pathogens and small molecules. https://doi.org/10.1289/EHP1878 Received: 09 March 2017 Revised: 14 August 2017 Accepted: 16 August 2017 Published: 28 September 2017 Address correspondence to M.B. Fessler, National Institute of Environmental Health Sciences, 111 T.W. Alexander Dr., P.O. Box 12233, Maildrop D2-01, Research Triangle Park, NC 27709 USA. Telephone: (919) 541-3701. Email: fesslerm@niehs.nih.gov *Current address: UN...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
We examined the effect of exposure to ambient PM10 on chronic symptoms and the pulmonary function tests (PFT) in diabetic and non-diabetic subjects. Also, to investigate possible determinants of susceptibility, we recruited 400 type 2 diabetic and 465 healthy subjects who were investigated for chronic respiratory symptoms (CRSs) and then underwent measurement of forced vital capacity (FVC) and forced expiratory volume 1 (FEV1) according to standard protocol. Percent predicted FEV1 and FVC (FEV1% and FVC%, respectively) for each subject were calculated. Particulate matter (PM10) concentrations at residence place of subjects...
Source: Environmental Science and Pollution Research International - Category: Environmental Health Authors: Tags: Environ Sci Pollut Res Int Source Type: research
ay CR Abstract Nutrition and the gut microbiome regulate many systems, including the immune, metabolic, and nervous systems. We propose that the host responds to deficiency (or sufficiency) of dietary and bacterial metabolites in a dynamic way, to optimize responses and survival. A family of G protein-coupled receptors (GPCRs) termed the metabolite-sensing GPCRs bind to various metabolites and transmit signals that are important for proper immune and metabolic functions. Members of this family include GPR43, GPR41, GPR109A, GPR120, GPR40, GPR84, GPR35, and GPR91. In addition, bile acid receptors such as GPR131 (TG...
Source: Annual Review of Immunology - Category: Allergy & Immunology Authors: Tags: Annu Rev Immunol Source Type: research
BackgroundPancreatic ductal adenocarcinoma (PDAC) is usually diagnosed in late adulthood; therefore, many patients suffer or have suffered from other diseases. Identifying disease patterns associated with PDAC risk may enable a better characterization of high-risk patients.MethodsMultimorbidity patterns (MPs) were assessed from 17 self-reported conditions using hierarchical clustering, principal component, and factor analyses in 1705 PDAC cases and 1084 controls from a European population. Their association with PDAC was evaluated using adjusted logistic regression models. Time since diagnosis of morbidities to PDAC diagno...
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
Conclusion and Clinical RelevanceGlucagon‐like peptide‐1 receptor is expressed on human eosinophils and neutrophils. A GLP‐1 analog attenuates LPS‐stimulated eosinophil activation. GLP‐1 agonists may have additional adjunctive indications in treating persons with concomitant type 2 diabetes mellitus and asthma.
Source: Clinical and Experimental Allergy - Category: Allergy & Immunology Authors: Tags: Original Article Source Type: research
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