Preliminary Results from a Phase 1 Study of HMPL-523, a Highly Selective Syk Inhibitor, in Chinese Patients with Mature B-Cell Lymphomas

Conclusions: HMPL-523 is well tolerated as a single agent in Chinese patients with R/R B-cell lymphomas. MTD was reached and RP2D was determined to be 600 mg QD. Preliminary anti-tumor activity was observed in indolent lymphomas, including CLL/SLL and FL.DisclosuresZhu: Beijing Cancer Hospital: Employment. Song: Peking University Cancer Hospital (Beijing Cancer Hospital): Employment. Hua: Hutchison Medipharma: Employment. Yang: Hutchison Medipharma: Employment. Yu: Hutchison Medipharma: Employment. Wang: Hutchison Medipharma: Employment. Dai: Hutchison Medipharma: Employment. Su: Hutchison Medipharma: Employment.
Source: Blood - Category: Hematology Authors: Tags: 623. Mantle Cell, Follicular, and Other Indolent B-Cell Lymphoma-Clinical Studies Source Type: research

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This article presents a unique 3D biocompatible Aluminum-based quantum structure (QS) for in vitro cancer detection using Surface Enhanced Raman Scattering (SERS). The Al-based QSs fabricated using ultrashort pulsed laser are of two distinct surface characters, wrinkled and smooth spherical. The limit of detection for chemical sensing of Crystal Violet and Rhodamine 6G by the Al-QS was driven up to single molecule sensing (femtomolar concentration). Biological sensing of cysteine, a disease biomarker and carcinoembryonic antigen (CEA), a cancer biomarker was also tested by the Al-QS. The ability of in vitro cell detection ...
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
In this study, four different weight% of Punica granatum fruit peel extract were used as green stabilizers to synthesize IONPs followed by a series of characterization experiments and in vitro anticancer evaluation. Results revealed that all synthesized IONPs have high degree of crystallinity and purity. The optimum saturation magnetization, and hydrodynamic size were found to be ∼69 emu.g−1, and 26.52 nm, respectively. Morphological studies demonstrated that adding peel extract decreased size of NPs with the average particle size below 11 nm. Cytotoxicity assay showed that the IONPs were not react...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Publication date: 15 March 2020Source: Journal of Molecular Structure, Volume 1204Author(s): A.D. Herrera-España, J. Us-Martín, S. Hernández-Ortega, G. Mirón-López, L. Quijano, J.R. Villanueva-Toledo, G.J. Mena-RejónAbstractThe structural modification of natural products has shown to be a remarkable tool in the generation of novel bioactive molecules. Herein, the synthesis, structural analysis and anticancer activity of the novel triterpenoid thiazole 3 is reported. The synthesis was carried out through the bromination of ochraceolide A (1) and the subsequent heterocyclic condensat...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Publication date: Available online 15 December 2019Source: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular BiologyAuthor(s): Shengming Sun, Ying Wu, Ivan Jakovlić, Hongtuo Fu, Xianping Ge, Hui Qiao, Wenyi Zhang, Shubo JinAbstractThe oriental river prawn, Macrobrachium nipponense, is a commercial freshwater prawn species in China. It is highly sensitive to hypoxia, and this has posed a challenge to its intensive culturing. To date, the effects of hypoxia on reproduction in female prawns are not entirely clear, as are the underlying mechanisms of the effects of hypoxia. In this work, comparative t...
Source: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology - Category: Molecular Biology Source Type: research
Publication date: Available online 14 December 2019Source: Chemico-Biological InteractionsAuthor(s): Ryan N. Serio, Lorraine J. GudasAbstractEthanol (EtOH) is a recreationally ingested compound that is both teratogenic and carcinogenic in humans. Because of its abundant consumption worldwide and the vital role of stem cells in the formation of birth defects and cancers, delineating the effects of EtOH on stem cell function is currently an active and urgent pursuit of scientific investigation to explicate some of the mechanisms contributing to EtOH toxicity. Stem cells represent a primordial, undifferentiated phase of devel...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
Publication date: Available online 14 December 2019Source: Sensors and Actuators B: ChemicalAuthor(s): Xinxin Shi, Yalei Hu, Hong-Min Meng, Jie Yang, Lingbo Qu, Xiao-Bing Zhang, Zhaohui LiAbstractIntracellular polarity has a large impact on the activity of a series of biomolecules or maintain the function of particular domains. Therefore, monitoring the changing of intracellular polarity can great improve the understanding its functions in living cell level. Herein, by employing p-phenylenediamine as precursor, we prepared a red emissive carbon dots based nanoprobe for real-time sensing polarity in living cells. With the i...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
Publication date: December 2019Source: Chinese Journal of Analytical Chemistry, Volume 47, Issue 12Author(s): Long-Chun BIAN, Cheng-Xiong WANG, Yan-Xiong LIU, Qiu-E CAO, Yun-Kun ZHAOAbstractThe thickness of washcoat loading on high-performance monolithic catalysts is normally determined by vernier caliper procedure, which gives rough result of washcoat thickness but does not address such parameters as morphology and homogeneity, accurate thickness of the layer and chemical composition of the coated layers in honeycomb-shaped monolithic catalysts. In this work, we proposed a methodology of washcoat analysis including the th...
Source: Chinese Journal of Analytical Chemistry - Category: Chemistry Source Type: research
In this study four kinds of fingerprints, including sweat, inkpad, sunscreen, and liquid foundation, were analyzed by air-flow assisted desorption electrospray ionization mass spectrometry imaging (AFADESI-MSI). AFADESI was employed with air flow of 45 L min−1, and 5 μL min−1 acetonitrile was used as spray solvent at spray voltage of 7000 V. Positive ion full scan mode (100−1000 Da) was chosen. The results showed that AFADESI-MSI method could not only obtain chemical information of various endogenous and exogenous substances in fingerprints, but also obtain high resolution images of fingerprints. In ad...
Source: Chinese Journal of Analytical Chemistry - Category: Chemistry Source Type: research
Publication date: December 2019Source: Chinese Journal of Analytical Chemistry, Volume 47, Issue 12Author(s): Hai-Lun XIA, Xin HUA, Yi-Tao LONGAbstractElectrode-electrolyte interface, where the electrochemical reaction happened, played an important role in the electrochemical mechanism investigation. The traditional electrochemical techniques paid more attention on the electron transfer process on the electrode but provided limited information of the electrochemical evolution at molecular level. Realizing the in-situ monitoring of the intermediates at the electrode-electrolyte interface during the redox reaction was essent...
Source: Chinese Journal of Analytical Chemistry - Category: Chemistry Source Type: research
Publication date: December 2019Source: Chinese Journal of Analytical Chemistry, Volume 47, Issue 12Author(s): Si-Jia LIANG, Ji-Kai MAO, Chen GONG, Dong-Dong YU, Jian-Guang ZHOUAbstractSample pretreatment is an important part in detection and analysis of samples, especially for those with low initial concentration. Preconcentration technology can improve the accuracy of analytical method and expand its application range. However, conventional sample preconcentration technology is often cumbersome, costly, time-consuming, and relies on expensive equipment. Paper-based microfluidic sample preconcentration technique has many a...
Source: Chinese Journal of Analytical Chemistry - Category: Chemistry Source Type: research
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