Increased Age-Related B-Cells in Patients with Aplastic Anemia

Conclusion: Although the number of patients analyzed is limited, our preliminary results suggest that aplastic anemia patients show expanded ABCs compared to age-matched control subjects, and these numbers are related to disease status. Further analysis of a larger pool of subjects is underway along with the examination of the specific transcription factor Bcl-6, that is implicated in T-bet expression in ABCs. These results will reveal the role of ABCs in the immune pathogenesis of aplastic anemia.Figure 1.DisclosuresKattamis: CELGENE: Consultancy, Honoraria; Vifor Pharma: Consultancy; Novartis: Consultancy, Honoraria; ApoPharma: Honoraria.

Source: Blood - November 21, 2018 Category: Hematology Authors: Solomou, E. E., Plakoula, E., Symeonidis, A., Galanopoulos, A., Vyniou, A., Nikolaos, G., Palasopoulou, M. D., Verigou, E., Vassilopoulos, G., Gogos, H., Kattamis, A., Liossis, S.-N. Tags: 508. Bone Marrow Failure Source Type: research