Rituximab for Immune Thrombocytopenia: A Retrospective Analysis on the Role of Prophylaxis Against Pneumocystis Jirovecii and Herpes Zoster Virus

ConclusionsIn our analysis, 11/20 (55%) patients of the cohort examinated received prophylaxis. Among the group who did not receive prophylaxis, these patients had a lower median age and one comorbidity only. In general, laboratory parameters did not show any persistent abnormality, neither clinically diagnosed infections occurred.Although the relatively small number of patients evaluted, the current analysis shows that prophylaxis against PJ and HZV infections is frequently adopted for ITP subjects receiving RTX and its potential beneficial effect. The role of prophylactic treatment to prevent viral and fungal infections in patients with ITP after RTX is far from being well-defined.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - Category: Hematology Authors: Tags: 311. Disorders of Platelet Number or Function Source Type: research