Understanding Disease Burden Among Persons with Hemophilia A without Inhibitors

ConclusionsThis study suggests that considerable clinical, emotional, and day-to-day disease burden exists in PwHA-WO, even among those with mild and moderate severity. Although joint bleed-related outcomes varied by severity, patients with moderate HA reported joint-related outcomes comparable to those with severe HA. However, limitation of daily activities did not differ by severity. PwHA-WO with mild, moderate and severe HA reported limitation in physical activities, which can impair their QoL. Better understanding of disease burden by severity among PwHA-WO will help in planning future interventions to address these burdens and improve health outcomes.DisclosuresOwens: Divitius LLC: Employment; Genentech Inc.: Consultancy; HFA: Consultancy. Cyhaniuk: Independent Contractor: Consultancy; HFA: Employment; AC Analytical Solutions, LLC: Employment. Patel: Genentech Inc: Employment. Raimundo: Genentech Inc: Employment, Other: Ownership interests PLC. Chan: Hemophilia Federation of America: Employment. Ko: Genentech Inc: Employment; F. Hoffmann-La Roche Ltd: Other: Ownership interests non-PLC.

Source: Blood - November 21, 2018 Category: Hematology Authors: Owens, W. E., Cyhaniuk, A., Patel, A., Raimundo, K., Chan, E., Ko, R. H. Tags: 901. Health Services Research-Non-Malignant Conditions: Poster III Source Type: research