Endocrinopathies Following Allogeneic Stem Cell Transplantation: 10 Years Follow-up in 402 Patients

ConclusionsAllo-HCT survivors are at relevant risk of endocrinopathies after transplantation, providing justification for specific monitoring to individualize treatment and follow-up. Of note, classical transplant-related variables are not enough to justify the occurrence of endocrinological disfunction: a further deeper evaluation of a misdiagnosed donor-mediated autoimmune predisposition will be essential.DisclosuresBonini: Intellia Therapeutics: Research Funding.
Source: Blood - Category: Hematology Authors: Tags: 723. Clinical Allogeneic and Autologous Transplantation: Late Complications and Approaches to Disease Recurrence: Poster III Source Type: research

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ConclusionsFindings suggest that self-harm behavior and psychiatric disorders are associated with increased ED utilization for subsequent chronic disease-related ED utilization. Chronic disease among adolescent psychiatric patients should be attended to, potentially involving new models of clinical follow-up care.
Source: Journal of Adolescence - Category: Child Development Source Type: research
Authors: Jeong HS, Hong SJ PMID: 30891965 [PubMed - as supplied by publisher]
Source: Korean Circulation Journal - Category: Cardiology Tags: Korean Circ J Source Type: research
In this study, to estimate the states that are not directly available from the Bergman minimal model a high-order sliding mode observer is proposed. Then fractional calculus is combined with sliding mode control (SMC) for blood glucose regulation to create more robustness performance and make more degree of freedom and flexibility for the proposed method. Then an adaptive fractional-order SMC is proposed. The adaptive SMC protect controller against disturbance and uncertainties while the fractional calculus provides robust performance. Numerical simulation verifies that the proposed controllers have better performance in t...
Source: IET Systems Biology - Category: Biology Source Type: research
Human pluripotent stem cell-derived cardiovascular progenitor cells (CPCs) are considered as powerful tools for cardiac regenerative medicine and developmental study. Mesoderm posterior1+ (MESP1+) cells are identified as the earliest CPCs from which almost all cardiac cell types are generated. Molecular insights to the transcriptional regulatory factors of early CPCs are required to control cell fate decisions. Herein, the microarray data set of human embryonic stem cells (hESCs)-derived MESP1+ cells was analysed and differentially expressed genes (DEGs) were identified in comparison to undifferentiated hESCs and MESP1-neg...
Source: IET Systems Biology - Category: Biology Source Type: research
This paper deals with the design of robust observer based output feedback control law for the stabilisation of an uncertain nonlinear system and subsequently apply the developed method for the regulation of plasma glucose concentration in Type 1 diabetes (T1D) patients. The principal objective behind the proposed design is to deal with the issues of intra-patient parametric variation and non-availability of all state variables for measurement. The proposed control technique for the T1D patient model is based on the attractive ellipsoid method (AEM). The observer and controller conditions are obtained in terms of linear mat...
Source: IET Systems Biology - Category: Biology Source Type: research
[Guardian] Researchers are unanimous that talc or talcum powder can cause lung, ovarian, stomach and endometrial (uterine) cancers. They said talc consisting of asbestos is generally accepted as being able to cause cancer if it is inhaled or/and used regularly in the genital area. Evidence on asbestos-free talc is however less clear.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
With almost half of British adults taking a daily vitamin,Graihagh Jackson and guests examine our love of supplements - including recent announcments about fortifying flour with folic acidAlmost half of adults in Britain take vitamins every day and wespend more on supplements than painkillers. This spring, the government will discuss whether to fortify flour with folic acid. The aim of the proposal is to prevent birth defects such as spina bifida by increasing folate intake in pregnant women.Graihagh Jackson looks atthe history of vitamins withDr Salim Al-Gailanifrom the University of Cambridge, discusses the forthcoming g...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Food science Diets and dieting Health & wellbeing Source Type: news
Could a simple blood test catch cancer before symptoms appear?Nicola Davis goes beyond the hype and investigates the future of blood diagnostics and cancerA blood test that could detect cancer earlier than current methods has long been a dream of oncologists. The hope is that these “liquid biopsies” could save countless lives by diagnosing cancer before symptoms show. They’re less invasive, quicker and easier than what is available now.However, this area of research has been plagued with hype. This happened most notably when a Silicon Valley startup –Theranos– allegedlyduped investors out of h...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Science Cancer research Medical research Source Type: news
Huazhang Wu, Fengchang Qiao, Yunli Zhao, Shouwei Wu, Minjie Hu, Tao Wu, Fuxin Huang, Wenjing Chen, Dengzhong Sun, Mulin Liu, Jinsong Zhao
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
ConclusionWe suggest educating patients and physicians to recognize changes in thyroid function and close monitoring of unclear cases of overt hyperthyroidism.
Source: Medical Principles and Practice - Category: Internal Medicine Source Type: research
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