Ruxolitinib Combined with Etanercept for Patients with Corticosteroid-Refractory Acute Graft Versus Host Disease after Allogeneic Stem Cell Transplantation: A Multi-Center Prospective Study

Conclusion: Combined treatment with ruxolitinib and etanercept resulted in a rapid CR to visceral aGVHD and meanwhile reserve graft anti-leukemia (GVL) effect as the relapse rate of primary disease is relatively lower. The various infection complications associated with ruxolitinib merit more attention.Figure.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - Category: Hematology Authors: Tags: 722. Clinical Allogeneic Transplantation: Acute and Chronic GVHD, Immune Reconstitution: Poster III Source Type: research

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In this study, P contents and oxygen isotope composition of inorganic phosphate (δ18OP) of different pools (H2O-P, NaHCO3-P, NaOH-P, and HCl-P) in typical agricultural soil from Northeast China and Central China were analyzed and quantified. The results showed that fertilizer and land use were important factors influencing the contents of H2O-Pt and NaHCO3-Pt and the soil TP contents from different types of soils were greatly affected by soil weathering degree. The δ18OP of different P pools indicated that the difference in utilization extent of different P fractions by microorganisms and the δ18OP values...
Source: Chemosphere - Category: Chemistry Authors: Tags: Chemosphere Source Type: research
This study investigated fluoride concentrations in 10 districts of Tianjin, China, to illustrate their spatial distribution characteristics and potential human health risks. The results showed fluoride concentration of 0.01-6.30 mg L-1 with a mean value of 0.99 mg L-1, and 78.82% of water fluoride reaches the standard for drinking water (1.5 mg L-1). Higher fluoride levels were recorded in deep well pumps supply zones, and more potential changes in fluoride occurred was positively correlated with pH in groundwater. Mean value of fluoride in drinking water in 10 districts followed the order of WQ > BC &...
Source: Chemosphere - Category: Chemistry Authors: Tags: Chemosphere Source Type: research
Abstract The occurrence, air-sea exchange, and gas-particle partitioning of polybrominated diphenyl ethers (PBDEs) were analyzed during a 2015 research expedition from the East China Sea (ECS) to the open Northwest Pacific Ocean (NWP). The sum of 13 PBDEs (Σ13PBDEs) in air and surface seawater varied in the range of 0.54-14.5. pg m-3 and 0.60-13.5 pg L-1, respectively, with the highest concentrations observed in the ECS. The Clausius-Clapeyron approach and air mass origin analysis indicated that continued primary emissions of PBDEs, particularly BDE-209, from East Asian sources governed the spatial varia...
Source: Chemosphere - Category: Chemistry Authors: Tags: Chemosphere Source Type: research
Abstract To investigate the effects of spatial expansion between native invasive species (Phragmites australis) and commom native species (Cyperus malaccensis) on variations of micro-elements (Pb, Cr, Cu, Zn, Ni, Cd and As) in decomposing litters in the Min River estuary, in situ filed decomposition experiment was conducted in P. australis (PA) community (before expansion, BE), C. malaccensis (CM) community (before expansion, BE) and P. australis-C. malaccensis (PA'-CM') community (during expansion, DE) from February 2016 to February 2017 by space-for- time substitution method. Results showed that t...
Source: Chemosphere - Category: Chemistry Authors: Tags: Chemosphere Source Type: research
Authors: Tosoni A, Paratore M, Piscitelli P, Addolorato G, De Cosmo S, Mirijello A, Internal Medicine Sepsis Study Group Abstract Procalcitonin (PCT) is a circulating polypeptide produced in response to bacterial infections. Studies conducted in the Intensive Care Unit (ICU) setting have demonstrated its utility as a biomarker of bacterial infection and sepsis. Thus, PCT is widely used to distinguish between sepsis and SIRS, and to guide antibiotic therapy. At present sepsis represents a frequent diagnosis among patients admitted to Internal Medicine (IM) departments. Basing on the knowledge derived from ICU studie...
Source: Panminerva Medica - Category: General Medicine Tags: Panminerva Med Source Type: research
Publication date: Available online 16 November 2019Source: Life SciencesAuthor(s): Yalda Jahanbani, Soudabe Davaran, Maryam Ghahremani-Nasab, Leili Aghebati-Maleki, Mehdi YousefiAbstractTissue engineering and the use of scaffolds have shown high therapeutic potentialities about male and female infertility. Nowadays, many couples are suffering from infertility problems. There are different causes for infertility including chemotherapy (for male and female), uterine injuries, and intrauterine adhesions. Extra-cellular matrix in tissue engineering provides a supportive medium for blood or lymphatic vessels making it a suitabl...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 16 November 2019Source: Advances in Space ResearchAuthor(s): Pengfei Zhang, Rui Tu, Wenjun Wu, Jinhai Liu, Xingxing Wang, Rui ZhangAbstractThe primary system of Chinese global BeiDou satellite system (BDS-3) was completed to provide global services on December 27, 2018; this was a key milestone in the development process for BDS in terms of its provision of global services. Therefore, this study analyzed the current performance of BDS-3, including its precise positioning, velocity estimation, and time transfer (PVT). The datasets were derived from international GNSS monitoring and assessm...
Source: Advances in Space Research - Category: Science Source Type: research
Conclusion: Chinese women had a substantially lower risk of venous thromboembolism during pregnancy and the postpartum period compared to that of Caucasians. The occurrence of pregnancy-related venous thromboembolism was largely confined to the early pregnancy period, probably related to the adoption of thromboprophylaxis, a lower rate of Cesarean section, and early mobilization. PMID: 31730677 [PubMed]
Source: Blood Research - Category: Hematology Tags: Blood Res Source Type: research
Authors: Fathi E, Sanaat Z, Farahzadi R Abstract Drug resistance in cancer, especially in leukemia, creates a dilemma in treatment planning. Consequently, studies related to the mechanisms underlying drug resistance, the molecular pathways involved in this phenomenon, and alternate therapies have attracted the attention of researchers. Among a variety of therapeutic modalities, mesenchymal stem cells (MSCs) are of special interest due to their potential clinical use. Therapies involving MSCs are showing increasing promise in cancer treatment and anticancer drug screening applications; however, results have been inc...
Source: Blood Research - Category: Hematology Tags: Blood Res Source Type: research
Authors: Kong JH, Nam H, Go TH, Hyun SY, Shim KY PMID: 31730680 [PubMed]
Source: Blood Research - Category: Hematology Tags: Blood Res Source Type: research
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