Does Use of Biosimilar G-CSF Change Plerixafor Utilization during Stem Cell Mobilization for Autologous Stem Cell Transplant?

Background: Autologous hematopoietic stem cell transplantation (AHSCT) is an important modality in the management of many hematologic malignancies. The first step for patients who are candidates for AHSCT is adequate stem cell collection. Recombinant granulocyte-colony stimulating factor (GCSF) is used for stem cell mobilization. Plerixafor has been used to increase the yield of mobilized stem cells, either upfront or pre-emptively when pre-apheresis peripheral blood CD34+ cell count is low. In the last few years, biosimilar G-CSF (Zarxio®) has become available. Although biosimilar G-CSF may reduce mobilization costs when used alone, the effect on use of additional mobilization agents like plerixafor has not been well studied. Therefore, we investigated whether there was a difference in the rate of Plerixafor usage among patients who were mobilized using biosimilar G-CSF (Zarxio®) compared to the original G-CSF (Neupogen®).Methods: This was a retrospective single institution study. We utilized the Karmanos Cancer Insitute's blood and marrow transplantation database to collect data on patients who underwent stem cell mobilization for AHSCT using either Neupogen® (N) or Zarxio® (Z), between January 2015 and June 2017. Per institutional policy, patients received G-CSF 10µg/Kg for 5 days and received Plerixafor if peripheral CD34+ cell count on the first planned day of collection was
Source: Blood - Category: Hematology Authors: Tags: 711. Cell Collection and Processing: Poster III Source Type: research

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We describe a contiguous gene deletion of the ATM locus in a multi-generation family of Italian descent with a strong family history of pancreatic cancer. A deletion of one copy of the entire ATM gene was identified by routine panel testing and further characterized by chromosomal microarray analysis. An 11q22.3 microdeletion of approximately 960kb was identified that is predicted to result in loss of 10 genes including ATM. The deletion was identified in two additional family members including a presymptomatic daughter and an affected sibling. A normal disomic complement of the 11q22.3 region was detected in a third famil...
Source: Cancer Genetics - Category: Cancer & Oncology Source Type: research
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Source: Revista Espanola de Medicina Nuclear e Imagen Molecular - Category: Nuclear Medicine Source Type: research
CONCLUSIONS IQGAP3 may be a potential target gene for Kaempferol in the treatment of BC, and upregulation of IQGAP3 inhibits Kaempferol-induced apoptosis in BC cells by ERK1/2 signaling activation. Targeting IQGAP3 may contribute to the study of natural phytochemicals as anti-tumor drugs in BC. PMID: 31605603 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
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Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
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Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
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Source: Stem Cell Research - Category: Stem Cells Source Type: research
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Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
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Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
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Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
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Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
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