Endogenous STAT3-Activated Wnt5a Provides CLL Cells with Survival Advantage

In conclusion: STAT3 induces the expression of both ROR1 and its ligand Wnt5a. In that way STAT3 activates a micoenvironment-independent pro-survival pathway in CLL cells.DisclosuresBose: Incyte Corporation: Honoraria, Research Funding; Celgene Corporation: Honoraria, Research Funding; Astellas Pharmaceuticals: Research Funding; Constellation Pharmaceuticals: Research Funding; Pfizer, Inc.: Research Funding; CTI BioPharma: Research Funding; Blueprint Medicines Corporation: Research Funding. Thompson: Genentech: Honoraria, Membership on an entity's Board of Directors or advisory committees; Gilead Sciences: Honoraria, Membership on an entity's Board of Directors or advisory committees; Adaptive Biotechnologies: Research Funding; AbbVie: Honoraria, Research Funding; Pharmacyclics: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding. Jain: Novimmune: Honoraria, Membership on an entity's Board of Directors or advisory committees; Pfizer: Research Funding; Pfizer: Research Funding; Janssen: Honoraria, Membership on an entity's Board of Directors or advisory committees; Janssen: Honoraria, Membership on an entity's Board of Directors or advisory committees; Incyte: Research Funding; Incyte: Research Funding; Seattle Genetics: Research Funding; Verastem: Honoraria, Membership on an entity's Board of Directors or advisory committees; Abbvie: Honoraria, Membership on an entity's Board of Directors or advisory committees; BMS: Research Fundi...

Source: Blood - November 21, 2018 Category: Hematology Authors: Rozovski, U., Li, P., Harris, D. M., Liu, Z., Jain, P., Ferrajoli, A., Burger, J. A., Bose, P., Thompson, P. A., Jain, N., Wierda, W. G., Keating, M. J., Estrov, Z. E. Tags: 641. CLL: Biology and Pathophysiology, excluding Therapy: Poster III Source Type: research