Phase 1b Dose Escalation Study of BI 836858 and Azacitidine in Previously Untreated AML: Results from Beat AML S2

Conclusions:This phase 1b sub-study of Beat AML demonstrates acceptable tolerability and activity of the combination of AZA with a novel CD33 glycoengineered antibody. Dose escalation as part of this sub-study continues, which will allow further assessment of efficacy and toxicity of this regimen in molecularly defined AML subsets.DisclosuresBlum: Forma: Research Funding; Tolero: Research Funding; Astellas: Consultancy; Boehringer Ingelheim: Research Funding; Pfizer: Consultancy; Xencor: Research Funding. Mims: Novartis: Consultancy; Abbvie Pharmaceuticals: Membership on an entity's Board of Directors or advisory committees; Agios Pharmaceuticals: Consultancy, Membership on an entity's Board of Directors or advisory committees. Stein: Daiichi Sankyo: Consultancy; Celgene: Consultancy; Bayer: Consultancy; Agios: Consultancy; Novartis: Consultancy; Pfizer: Consultancy. Odenike: Celgene: Consultancy, Membership on an entity's Board of Directors or advisory committees; Janssen: Research Funding; Gilead Sciences: Research Funding; Celgene: Research Funding; Agios: Research Funding; Oncotherapy Science: Research Funding; Jazz Pharmaceuticals: Consultancy, Membership on an entity's Board of Directors or advisory committees; Incyte: Consultancy, Membership on an entity's Board of Directors or advisory committees; Dava Oncology: Consultancy, Membership on an entity's Board of Directors or advisory committees; CTI/Baxalta: Consultancy, Membership on an entity's Board of Directors or ad...

Source: Blood - November 21, 2018 Category: Hematology Authors: Blum, W., Ruppert, A. S., Mims, A. S., Stein, E. M., Duong, V. H., Odenike, O., Patel, P. A., Kovacsovics, T., Heerema, N. A., Vergilio, J.-A., Rosenberg, L., Marcus, S., Stefanos, M., Weiner, H., Brandt, J., Shoben, A., Druker, B. J., Burd, A., Levine, R Tags: 616. Acute Myeloid Leukemia: Novel Therapy, excluding Transplantation: Poster III Source Type: research