Combining Parthenolide and Sulfasalazine Improves Toxicity to CD200+ LIC Populations in Childhood ALL

In conclusion, this study has shown that PTL was very effective against unsorted and all CD200+ or CD200- subpopulations in both low risk and risk BCP ALL cases, confirming its potential as an effective agent in ALL, which is not limited by surface marker expression on target cells. While sensitivity to PTL was reduced in the presence of MSC, it was largely regained with the use of SSZ in the unsorted and CD34+/CD200+ cells in low risk cases and CD34-/CD200+ cells in the risk cases, indicating CD200+ LIC could be effectively targeted using this combination. These data highlight the importance of combining cancer therapies with agents that restrict the effects of the microenvironmental niche to overcome drug resistance in cancer.DisclosuresNo relevant conflicts of interest to declare.

Source: Blood - November 21, 2018 Category: Hematology Authors: Diamanti, P., Al-Masri, A., Ede, B. C., Blair, A. Tags: 614. Acute Lymphoblastic Leukemia: Therapy, excluding Transplantation: Poster III Source Type: research