Gut Colonization with Carbapenem Resistant Enterobacteriaceae(CRE) Leads to More Chemotherapy Inerruptions and Higher Mortality in Patients with Acute Leukemias Receiving Remission Induction Chemotherapy

Conclusion:More than half of the patients with acute leukemia had CRE colonization of the gut at the time of presentation. Chemotherapy interruptions and deaths during induction were seen in a significantly higher number of patients colonized with CRE at the time of presentation. Patients with acute leukemia should be screened for CRE colonization of the gut prior to induction chemotherapy. This assumes importance is centres with high prevalence of CRE colonization as CRE colonisation of the gut is a predictor for induction mortality.References:J. de Naurois, I. Novitzky-Basso, M.J. Gill etal, Management of febrile neutropenia ESMO guidelines. Annals of Oncology, (2010) 21 (suppl_5): v252-v256Collin BA, Leather HL, Wingard JR etal, Evolution, incidence, and suspecitibility of bacterial blood stream isolates from 519 bone marrow transplant patients. Clin Ifect Dis. 2001:33(7):947-53Neil Gupta, Brandi M, Limbago et al, Carbapenem-Resistant Enterobacteriaceae: Epidemiology and Prevention, Healthcare Epidemiology, CID 2011:53 (1 July)Mathews, V., Srivastava, A., George, B., Korula, A., Perumalla, S., Abubacker, F. N., N, N. P., Devasia, A., Abraham, A., Balaji, V., & Lakshmi, K. M. (2016).Multi-Drug Resistant Organisms Are Common in Fecal Surveillance Cultures and Do Not Predict Bacteremia but Correlate with Poorer Outcomes in Patients Undergoing Allogeneic Stem Cell Transplants. Blood, 128(22), 3406DisclosuresSeth: Shire: Honoraria.
Source: Blood - Category: Hematology Authors: Tags: 613. Acute Myeloid Leukemia: Clinical Studies: Poster III Source Type: research