ESAM on the Cells of Endothelial Lineage Plays an Important Role in the Development of Definitive Hematopoiesis

In conclusion, our data strongly suggest that ESAM expression on ECs, as well as HSCs, plays an important role in the development of definitive hematopoiesis. ESAM is known to mediate cell-cell interaction through homophilic binding. The results showed that ESAM on ECs in the developing liver compensated for ESAM deficiency on HSCs to ameliorate the lethal anemic phenotype. This indicates that ESAM might interact with undetermined molecules on developing HSCs, and these molecules might have a functional overlap with ESAM.DisclosuresYokota: CHUGAI PHARMACEUTICAL CO., LTD.: Research Funding; Pfizer Inc.: Research Funding; Bristol-Myers Squibb: Research Funding; MSD K.K.: Research Funding; Celgene: Research Funding. Ichii: Celgene K.K.: Speakers Bureau; Kowa Pharmaceutical Co.,LTD.: Speakers Bureau; Novartis Pharma K.K.: Speakers Bureau. Ezoe: TAIHO Phamaceutical Co., Ltd.: Research Funding. Shibayama: Takeda Pharmaceutical Co.,LTD.: Honoraria, Research Funding; Fujimoto Pharmaceutical: Honoraria, Research Funding; Bristol-Meyer Squibb K.K: Honoraria, Research Funding; Ono Pharmaceutical Co.,LTD: Honoraria, Research Funding; Novartis Pharma K.K.: Honoraria, Research Funding; Jansen Pharmaceutical K.K: Honoraria; Mundipharma K.K.: Honoraria, Research Funding; Celgene K.K.: Honoraria, Research Funding. Oritani: Novartis Pharma: Speakers Bureau. Kanakura: Alexion Pharmaceuticals, Inc.: Consultancy, Honoraria, Research Funding.

Source: Blood - November 21, 2018 Category: Hematology Authors: Ueda, T., Yokota, T., Uno, Y., Mashimo, T., Sudo, T., Ishibashi, T., Doi, Y., Shingai, Y., Tanimura, A., Ichii, M., Ezoe, S., Shibayama, H., Oritani, K., Kanakura, Y. Tags: 506. Hematopoiesis and Stem Cells: Microenvironment, Cell Adhesion, and Stromal Stem Cells: Poster III Source Type: research