The BCL-2-Selective Inhibitor Venetoclax Spares Activated T-Cells during Anti-Tumor Immunity

Conclusions:These data suggest that venetoclax treatment results in loss of naïve but not memory T cells. Venetoclax did not affect the viability, the induction or frequency of memory T cells. In human in vitro experiments and in an in vivo syngeneic tumor model venetoclax did not antagonize the therapeutic effect of anti-PD-1. Contrary to our initial hypothesis, we find that modulation of the immune system by venetoclax may support its potential use for immune-based cancer therapy, as memory T-cells can rapidly acquire effector and cytotoxic function to eliminate cancer cells. Taken together, we provide evidence that venetoclax in combination with immune checkpoint inhibitors should be further explored as a therapy for cancer patients.All authors are employees of AbbVie. The design, study conduct, and financial support for this research were provided by AbbVie. AbbVie and Genentech participated in the interpretation of data, review, and approval of the publication.DisclosuresMathew: AbbVie Inc.: Employment. Haribhai: AbbVie Inc.: Employment. Kohlhapp: AbbVie Inc.: Employment. Duggan: AbbVie Inc.: Employment. Ellis: AbbVie Inc.: Employment. Riehm: AbbVie Inc.: Employment. Robinson: AbbVie Inc.: Employment. Shi: AbbVie Inc.: Employment. Bhathena: AbbVie Inc.: Employment. Leverson: AbbVie Inc: Employment, Equity Ownership, Patents &Royalties. Pappano: AbbVie Inc.: Employment. Donawho: AbbVie Inc.: Employment. Uziel: AbbVie Inc.: Employment.
Source: Blood - Category: Hematology Authors: Tags: 203. Lymphocytes, Lymphocyte Activation, and Immunodeficiency, including HIV and Other Infections: Poster III Source Type: research

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hez E Abstract PMID: 31309875 [PubMed - in process]
Source: Current Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Curr Stem Cell Res Ther Source Type: research
ConclusionsComplete perioperative colonoscopy in patients with CRC should be performed to reduce the rate of metachronous carcinoma. Postoperative completion of preoperative insufficiently colonoscoped patients is recommended.
Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
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Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
AbstractPurposeMost elderly patients with colorectal cancer have comorbidities and reduced functional reserve, which may increase their risks of postoperative morbidity and mortality, and subsequently influence the treatment choice. Therefore, this study aimed to investigate the treatment choice and compare laparoscopic and open surgery in this setting.MethodsThis retrospective study evaluated 118 patients with colorectal cancer ( ≥ 85 years old between January 2007 and February 2018) to determine the influence of comorbidities on treatment choice, as well as the safety and feasibility of laparoscopic s...
Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
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Source: Journal of Maxillofacial and Oral Surgery - Category: ENT & OMF Source Type: research
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Source: Journal of Maxillofacial and Oral Surgery - Category: ENT & OMF Source Type: research
This article mentions key results that lead to a new perspective where cancer stem cells are primarily seen as cells exhibiting increased epigenetic plasticity and increased gene expression variability. This perspective suggests new therapeutical interventions consisting in stabilizing gene expression to control cancer cell proliferation and prevent stochastic gene expression variations that could lead to therapeutic resistance. PMID: 31308849 [PubMed]
Source: Journal of Oncology - Category: Cancer & Oncology Tags: J Oncol Source Type: research
We describe the management of cancer-associated IO near the end of life in a population-based cohort with universal health coverage. METHODS: Patients who died of gastric, colorectal, ovarian, and pancreatic cancers from 2002 to 2015 were identified from the Ontario Cancer Registry. Those with ≥1 hospital admission for IO in the final year of life were identified from administrative data. Management of IO at index admission was categorized as surgery, gastrostomy, stent, feeding jejunostomy, and medical management. Trends in management over the study period were assessed by the Cochran-Armitage test. RESULTS: Th...
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