Allergic Sensitization Is Associated with Decreased Risk of ED Visits and Hospitalizations for Pain in Sickle Cell Disease

Conclusions: In a population of children with SCD, allergic sensitization was associated with decreased risk of ED visits (total, for pain, and for fever). The mechanism for an association between atopy and a less severe phenotype of SCD is unclear. These findings point to potential differences in immunologic endotype/phenotype and add support to the hypothesis that lower airway disease in children with SCD has a different mechanism than typical childhood atopic asthma. Further investigation into the immunologic phenotypes and mechanisms of lower airway disease in children with SCD is warranted.1All IRR presented are per allergen, adjusted for age, sex, hydroxyurea use, and HOH education level; 95% confidence interval.DisclosuresStrouse: Global Blood Therapeutics: Consultancy.
Source: Blood - Category: Hematology Authors: Tags: 114. Hemoglobinopathies, Excluding Thalassemia-Clinical: Poster III Source Type: research

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Publication date: Available online 25 January 2020Source: Journal of OrthopaedicsAuthor(s): Curtis T. Adams, Akshay LakraABSTRACTHip joint subluxation and dislocations are very common in cerebral palsy (CP) patients and are directly related to the degree of spasticity. Hip dislocation and subluxation leads to hip pain and difficulty in hygiene maintenance by caregiver. Most cases require some sort of surgical intervention to improve the quality of life in these patients. For many years’ pelvic and proximal femoral osteotomies with soft tissue releases was the main stay of treatment for these hips in CP patients. Hip ...
Source: Journal of Orthopaedics - Category: Orthopaedics Source Type: research
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In this study, we investigated the anti-inflammatory protective effect of interleukin-1 receptor antagonist (IL-1ra), an anti-inflammatory cytokine, on systemic lipopolysaccharide (LPS)-induced spinal cord inflammation and oxidative stress, thermal hyperalgesia, and mechanical allodynia in neonatal rats. Intraperitoneal (i.p.) injection of LPS (2 mg/kg) or sterile saline was performed in postnatal day 5 (P5) rat pups, and IL-1ra (100 mg/kg) or saline was administered (i.p.) 5 min after LPS injection. Pain reflex behavior, spinal cord inflammation and oxidative stress were examined 24 h after LPS adminis...
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Corrigendum to "Yokukansan Alleviates Cancer Pain by Suppressing Matrix Metalloproteinase-9 in a Mouse Bone Metastasis Model". Evid Based Complement Alternat Med. 2019;2019:3513064 Authors: Nakao K, Fujiwara A, Komasawa N, Jin D, Kitano M, Matsunami S, Takai S, Ito S, Minami T Abstract [This corrects the article DOI: 10.1155/2019/2956920.]. PMID: 31975997 [PubMed - in process]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
In this study, we show that CRISPR/Cas9 can also be used to efficiently change functional properties of the proteins encoded by the target gene by on-site genomic mutations in A. niger. The obtained strains with constitutively active XlnR and GaaR versions resulted in increased production of plant biomass degrading enzymes and improved release of D-xylose and L-arabinose from wheat bran, and D-galacturonic acid from sugar beet pulp.
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Publication date: 25 January 2020Source: New Scientist, Volume 245, Issue 3266Author(s): Clare WilsonCurrent baby weaning guidelines may mean we are missing a crucial window to prevent food allergies. Clare Wilson reports
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Source: Journal of Agromedicine - Category: Environmental Health Authors: Source Type: research
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Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
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Source: Arthroscopy Techniques - Category: Surgery Source Type: research
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