Prophylaxis of Chemotherapy-Induced Nausea and Vomiting with Fosaprepitant and Granisetron in Pediatric Patients after Allogeneic HSCT

ConclusionsThe prophylaxis regimen with fosaprepitant in combination with granisetron was safe and more effective in comparison to the standard prophylaxis regimen with granisetron only in pediatric patients undergoing allogeneic HSCT with a myeloablative conditioning. However, larger prospective trials are needed to evaluate these findings.5. KeywordsChemotherapy-induced nausea and vomiting; antiemetic prophylaxis; fosaprepitant; pediatric patients6. AcknowledgementsThis study was supported by the Stefan-Morsch-Stiftung, Birkenfeld, Germany.DisclosuresSchlegel: Miltenyi Biotec: Patents & Royalties, Research Funding. Seitz: Miltenyi Biotec: Patents & Royalties, Research Funding. Lang: Miltenyi Biotec: Patents & Royalties, Research Funding. Handgretinger: Miltenyi Biotec: Patents & Royalties: Co-patent holder of TcR alpha/beta depletion technologies, Research Funding.

Source: Blood - November 21, 2018 Category: Hematology Authors: Cabanillas Stanchi, K. M., Vek, J., Schlegel, P., Seitz, C. M., Rupprecht, J., Schober, S., Michaelis, S., Malaval, C., Flaadt, T., Schnaufer, L., Queudeville, M., Feucht, J., Lang, P., Handgretinger, R., Doring, M. Tags: 721. Clinical Allogeneic Transplantation: Conditioning Regimens, Engraftment, and Acute Transplant Toxicities: Poster II Source Type: research