Whole Blood Transcriptional Profiling Reveals Highly Deregulated Atherosclerosis Genes in Myeloproliferative Cancer

In conclusion, we have for the first time shown massive deregulation of atherosclerosis genes in MPNs, likely reflecting the inflammatory state in MPNs in association with in vivo activation of the cell types (leukocytes, platelets, endothelial cells) being deeply involved in the atherosclerotic process. The significance of our observations should be further explored and confirmed in other MPN-cohorts and the impact of cytoreductive therapy (e.g interferon-alpha2) and statins upon deregulated genes as well.DisclosuresHasselbalch: Novartis: Research Funding.

Source: Blood - November 21, 2018 Category: Hematology Authors: Skov, V., Thomassen, M., Kjaer, L., Riley, C., Larsen, T. S., Bjerrum, O. W., Kruse, T. A., Hasselbalch, H. C. Tags: 635. Myeloproliferative Syndromes: Basic Science: Poster II Source Type: research