Phase 1/2 Trial of Durvalumab and Lenalidomide in Patients with Cutaneous T Cell Lymphoma (CTCL): Preliminary Results of Phase I Results and Correlative Studies

Conclusions: Durvalumab/lenalidomide has significant clinical activity in patients with refractory/advanced CTCL, which will be formally evaluated in the Phase 2 portion of this trial. Responses were durable and ongoing, and treatment was well tolerated with a low toxicity profile. Dose escalation is planned up to lenalidomide 20 mg daily. Our preliminary results from patients on trial demonstrated that immune signatures on skin biopsies at baseline may be predictive of response to checkpoint blockade and yield insights into mechanisms of therapeutic resistance.DisclosuresQuerfeld: Acelion: Membership on an entity's Board of Directors or advisory committees; Kyowa: Membership on an entity's Board of Directors or advisory committees; Bioniz: Membership on an entity's Board of Directors or advisory committees; Medivir: Membership on an entity's Board of Directors or advisory committees; Trillium Therapeutics: Membership on an entity's Board of Directors or advisory committees.
Source: Blood - Category: Hematology Authors: Tags: 624. Hodgkin Lymphoma and T/NK Cell Lymphoma-Clinical Studies: Poster II Source Type: research

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Source: Journal of Neuroscience Nursing - Category: Neuroscience Tags: Articles Source Type: research
ConclusionsPatient experiences related toH. pylori management are predominantly negative. Increasing providers ’ awareness about patients’ values, beliefs, anxieties, and expectations surroundingH. pylori diagnosis/treatment may improve provider-patient communication and, ideally, related outcomes.
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
Oncogene, Published online: 16 January 2022; doi:10.1038/s41388-021-02151-3The critical role of STAT3 in biogenesis of tumor-derived exosomes with potency of inducing cancer cachexia in vitro and in vivo
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AS CONCERNS about disease spread, a growing body of experts are investigating which unknown health boosters could pave the way to a longer lifespan. In the pursuit of longevity, one lesser-known herb has been shown to be highly effective.
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CANCEROUS cells multiplying in the stomach can lead to notoriously "hard to spot" symptoms. However, once you are aware of the warning signs, you can seek medical assistance should they arise.
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People who experience debilitating back pain come to their doctors with one pressing question: Do I need back surgery? Often, they are surprised to hear me, a neurosurgeon, answer, “No.” In many cases, physical therapy, pain management, weight loss management, and physiatry can help people to delay – and in some cases avoid – backRead more …Expertise is the backbone of successful spine treatment originally appeared inKevinMD.com.
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Vitamin D supplementation could lower the risk of dying from cancer-related diseases and increase life expectancy by years.
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Nutrition Source Type: blogs
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