Epidemiology and Survivorship of Anaplastic Large Cell Lymphoma

DISCUSSION:This is the largest and most comprehensive study to date on the epidemiology and prognostic factors of Anaplastic Large Cell Lymphoma. The results of our analysis bring up several interesting trends, the most interesting one being the marked increase in survival rates between 2010- 2015 compared to 2004-2009. This is likely attributed to better treatment modalities. With regards to treatment modalities, patients who underwent chemotherapy followed by adjuvant transplant had better 1, 3, 5 and 10 year survival rates compared to all other treatment modalities. As previously established, younger age at diagnosis is a good prognosis factor. Other major factors influencing survival, previously unstudied, are facility type, race, insurance status, stage, adjuvant therapy, and primary site. Asians and those with private insurance had better survival rates. Primary site involving multiple lymph nodes carried the worst prognosis, while lower limb and hip as primary sites carried the best prognosis. Patients treated at academic and research center had better prognosis compared to those treated at non- academic centers. Performing a multi-variate analysis and further studies to elucidate the causes of improved survival associated with some of these factors will help improve quality of care for patients with ALCL.Table.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - Category: Hematology Authors: Tags: 624. Hodgkin Lymphoma and T/NK Cell Lymphoma-Clinical Studies: Poster II Source Type: research