Phase I-II Study of Crenolanib Combined with Standard Salvage Chemotherapy and Crenolanib Combined with 5-Azacitidine in Acute Myeloid Leukemia Patients with FLT3 Activating Mutations
Conclusion: Full dose crenolanib (100 mg TID) can be safely combined with chemotherapy in R/R FLT3 mutant AML. ORR can reach up to 50% with the combination, even with prior exposure to FLT3 inhibitors, and particularly among Arm 1 pts with ≤ 2 prior therapies (mOS=8.6 mo). The study was terminated at the sponsor's request.DisclosuresJabbour: Takeda: Consultancy, Research Funding; Novartis: Research Funding; Pfizer: Consultancy, Research Funding; Abbvie: Research Funding; Bristol-Myers Squibb: Consultancy, Research Funding. Wierda: Genentech: Research Funding; AbbVie, Inc: Research Funding. Daver: ImmunoGen: Consultancy; Alexion: Consultancy; Pfizer: Research Funding; Otsuka: Consultancy; Novartis: Consultancy; Sunesis: Research Funding; Karyopharm: Consultancy; Pfizer: Consultancy; Kiromic: Research Funding; BMS: Research Funding; ARIAD: Research Funding; Sunesis: Consultancy; Daiichi-Sankyo: Research Funding; Novartis: Research Funding; Incyte: Research Funding; Karyopharm: Research Funding; Incyte: Consultancy. Konopleva: Stemline Therapeutics: Research Funding. Andreeff: SentiBio: Equity Ownership; Aptose: Equity Ownership, Membership on an entity's Board of Directors or advisory committees; Oncolyze: Equity Ownership; Daiichi-Sankyo: Consultancy, Patents & Royalties: MDM2 inhibitor activity patent, Research Funding; Celgene: Consultancy; Oncoceutics: Equity Ownership, Membership on an entity's Board of Directors or advisory committees; Astra Zeneca: Research Fundin...
Source: Blood - Category: Hematology Authors: Aboudalle, I., Kantarjian, H. M., Ohanian, M. N., Alvarado, Y., Jabbour, E. J., Garcia-Manero, G., Naqvi, K., Wierda, W. G., Daver, N. G., Burger, J. A., Konopleva, M. Y., Takahashi, K., Andreeff, M., Pemmaraju, N., Ferrajoli, A., Borthakur, G., Kadia, T. Tags: 616. Acute Myeloid Leukemia: Novel Therapy, excluding Transplantation: Poster II Source Type: research
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