The Effect of Asparaginase on Serum Triglycerides during Therapy for Acute Lymphoblastic Leukemia

Conclusions: These data support a greater association of PEG-ASP than L-ASP with elevation of serum TGs, and a greater effect of ASP than DEX. Whether serum hyperTG contributes to toxicities such as thrombosis or osteonecrosis, or is a biomarker of greater drug exposure or sensitivity, is unclear.Figure.DisclosuresInaba: Shire: Research Funding. Relling: Shire Pharmaceuticals: Research Funding.

Source: Blood - November 21, 2018 Category: Hematology Authors: Finch, E. R., Smith, C. A., Yang, W., Kornegay, N. M., Panetta, J. C., Crews, K. R., Molinelli, A. R., Cheng, C., Pei, D., Ramsey, L. B., Karol, S. E., Inaba, H., Sandlund, J. T., Metzger, M., Evans, W. E., Jeha, S., Pui, C.-H., Relling, M. V. Tags: 612. Acute Lymphoblastic Leukemia: Clinical Studies: Poster II Source Type: research