Tissue Factor Pathway Inhibitor Enhances Transendothelial Migration of Chronic Lymphocytic Leukemia Cells through Binding to Glypican-3

In this study, we show that TFPI enhances CLL cell migration through binding to glypican-3 and activating Wnt/β-catenin signaling pathway. Our findings suggest a novel molecular mechanism regulating the transmigration of leukemic cells. It may open a new window for therapeutic targeting in the treatment of organ infiltration of CLL patients.DisclosuresNo relevant conflicts of interest to declare.

Source: Blood - November 21, 2018 Category: Hematology Authors: Cui, X., Tjonnfjord, G. E., Kanse, S., Iversen, N., Dahm, A. E., Myklebust, C. F., Sun, L., Jiang, Z. X., Ho, M., Sandset, P. M. Tags: 321. Blood Coagulation and Fibrinolytic Factors: Poster II Source Type: research