Haploidentical Transplantation with Regulatory and Conventional T Cells Improves Outcome of Patients Affected By Acute Myeloid Leukemia with Complex Karyotype and/or Monosomy 7/Del(7q)
In conclusion, our results not only confirm that HSCT is the only potentially curative treatment for AML with complex karyotype and/or chromosome 7 involvement, but also demonstrate that Treg-Tcon haplo-HSCT allows for a strong antileukemic effect, the only needed for a long term control of such unfavorable AMLs with high disease burden at transplant. While it is necessary to confirm these results in a larger cohort of patients, Treg-Tcon haplo-HSCT could represent the best transplant option for this subset of very high-risk AML patients.Figure.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - Category: Hematology Authors: Pierini, A., Marra, A., Carotti, A., Ruggeri, L., Terenzi, A., Falzetti, F., Piccinelli, S., Cardinali, V., Mancusi, A., Tardioli, C., Felicini, R., Lucia, A., Casarola, G., Tricarico, S., Bonato, S., Paradiso, M., Griselli, M., Crescenzi, B., La Starza, Tags: 732. Clinical Allogeneic Transplantation: Results: Poster I Source Type: research
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