Prediction of Hepatic Complications after Allogeneic Haemotopoetic Stem Cell Transplantation Using Liver and Spleen Stiffness Measurement

Conclusions: Elevated liver stiffness assessed by either TE or pSWE is associated with an increased risk for liver related complications including SOS, non-relapse mortality and decreased survival after allogeneic HCT. LSM should be evaluated further as a potential additional prognostic marker in the comorbidity assessment before transplant. Pts at higher risk for liver related events could be subject to additional prophylaxis such as defibrotide for the prevention of SOS.DisclosuresFranke: Novartis: Consultancy, Honoraria, Research Funding; Pfizer: Consultancy; Jazz: Honoraria. Niederwieser: Miltenyi: Speakers Bureau; Novartis: Research Funding.

Source: Blood - November 21, 2018 Category: Hematology Authors: Franke, G.-N., Weisse, T., Petroff, D., Beer, S., Dohring, C., Behre, G., Fischer, J., Lindner, F., Wiegand, J., Keim, V., Niederwieser, D., Karlas, T. Tags: 721. Clinical Allogeneic Transplantation: Conditioning Regimens, Engraftment, and Acute Transplant Toxicities: Poster I Source Type: research