Pharmacokinetic-Pharmacodynamic Analyses to Provide Rezafungin Prophylaxis Dose Selection for Prevention of Invasive Fungal Infections for Bone Marrow Transplant Patients

Conclusions: These data provide support for a once-weekly rezafungin dosing regimen for prevention of A. fumigatus infections among BMT patients. The effectiveness of current antifungal prophylactic regimens is frequently limited by safety, tolerability, drug interactions, adherence, pill burden and patient factors such as mucositis or background chemotherapeutic regimens. In addition to the excellent safety, tolerability, and lack of drug interactions exhibited by echinocandin agents, the favorable PK profile of rezafungin presents the opportunity to mitigate the typical challenges faced when administering IFI prophylaxis in BMT and other immunocompromised patients.DisclosuresLakota: Cidara Therapeutics: Research Funding. Flanagan: Cidara Therapeutics: Employment, Equity Ownership. Sandison: Cidara Therapeutics: Employment, Equity Ownership. Brown: Cidara Therapeutics: Consultancy. Rubino: Cidara Therapeutics: Research Funding.
Source: Blood - Category: Hematology Authors: Tags: 721. Clinical Allogeneic Transplantation: Conditioning Regimens, Engraftment, and Acute Transplant Toxicities: Poster I Source Type: research

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Conclusions: The porcine biomodel is a viable tool in translational research applied to the understanding of the respiratory system anatomy and the training in lung transplantation. The implementation of this experimental model has the potential to strength the groups who plan to implement an institutional program of lung transplantation in humans. PMID: 31529817 [PubMed - in process]
Source: Biomedica : Revista del Instituto Nacional de Salud - Category: International Medicine & Public Health Tags: Biomedica Source Type: research
An artificial intelligence (AI) algorithm was able to automatically quantify...Read more on AuntMinnie.comRelated Reading: Ultrasound useful for evaluating liver steatosis MRI offers view of liver fat loss in obese patients Ultrasound options abound for diagnosing liver disease AIUM: Can deep learning classify liver fibrosis on US? Fatty liver disease occurs with risky plaque
Source: Headlines - Category: Radiology Source Type: news
Contributors : Marc Clement ; Ziad Mallat ; Dimitrios Tsiantoulas ; Marcella Ma ; Brian LamSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAnalysis of the transcriptional signature of FACS-purified splenic DC subsets from Ldlr deficient mice transplanted with control or Cd11c-cre Atg16l1flox/flox bone marrow and subjected to an atherogenic diet for 8 weeks
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
In conclusion, the anti-leukemic activity of ATG, particularly CDC, is more potent for ALL than AML in vitro. If this applies in vivo, ATG-based GVHD prophylaxis may be particularly advantageous for ALL.
Source: Cytotherapy - Category: Cytology Source Type: research
Authors: Guo Y, Meng Y, Liu H, Wang B, Ding C, Rong X, Yang Y, Hong Y Abstract To elucidate the pathological significance of acid-sensing ion channels (ASICs) in intervertebral disc degeneration (IVDD), the database of Medline, Web of Science, and EmBase were carefully screened. Search terms used in each database varied slightly to optimize results. Data relating to the correlation between ASICs and IVDD was systematically collected and integrated into the review. 11 basic science studies, containing the related information, were finally identified for inclusion. Intervertebral disc degeneration (IVDD) is a common ...
Source: Channels - Category: Molecular Biology Tags: Channels (Austin) Source Type: research
Abstract Biosorbents prepared with peanut shell and wheat straw were act as supports for the immobilization of Aspergillus laccase, and the redox mediator syringaldehyde (SA) was used to improve laccase-catalyzed degradation of nine pesticide residues, including isoproturon, atrazine, prometryn, mefenacet, penoxsulam, nitenpyram, prochloraz, pyrazosulfuron-ethyl and bensulfuron-methyl. Pesticides in water and soil samples were effectively removed via biosorbent concentration and subsequent immobilized laccase degradation on peanut shell or wheat straw supports. The Langmuir equation and Freundlich equation describ...
Source: Chemosphere - Category: Chemistry Authors: Tags: Chemosphere Source Type: research
This study sought to create a risk stratification model using only preoperative recipient data to predict 1-year postoperative mortality during the pretransplant assessment.MethodsData of lung transplant recipients at Houston Methodist Hospital in Houston, Texas from January 2009 to December 2014 were extracted from the United Network for Organ Sharing (UNOS) database. Patients were randomly divided into development and validation cohorts. Cox proportional-hazards models were conducted. Variables associated with 1-year mortality after transplantation were assigned weights on the basis of the beta coefficients, and ris...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
ConclusionsReLTx is a reasonable option for a selected group of patients. Ideally, a number of well-established risk factors are avoided and the ReLTx is performed more than 1 year after the PLTx.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Publication date: October 2019Source: The Annals of Thoracic Surgery, Volume 108, Issue 4Author(s): Nicolas d’Ostrevy, Adama Sawadogo, Jean Porterie, Vedat Eljezi, Etienne Geoffroy, Lucie Cassagnes, Lionel CamilleriLeft ventricular unloading during extracorporeal life support aims to minimize potential side effects of increased left ventricular afterload. A transaortic catheter vent implanted through a subclavian approach was used in 2 patients. Patient 1 was a 48-year-old man with a recent history of ST-elevation myocardial infarction who developed refractory cardiogenic shock due to severe biventricular dysfunction...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Publication date: October 2019Source: The Annals of Thoracic Surgery, Volume 108, Issue 4Author(s): Jordan J. Lancaster, Pablo Sanchez, Giuliana G. Repetti, Elizabeth Juneman, Amitabh C. Pandey, Ikeotunye R. Chinyere, Talal Moukabary, Nicole LaHood, Sherry L. Daugherty, Steven GoldmanBackgroundTo treat chronic heart failure (CHF), we developed a robust, easy to handle bioabsorbable tissue-engineered patch embedded with human neonatal fibroblasts and human induced pluripotent stem cell–derived cardiomyocytes (hiPSC-CMs). This patch was implanted on the epicardial surface of the heart covering the previously infarcted ...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
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