Blockade of Mer By the Small Molecule Inhibitor R992 Inhibits Multiple Myeloma and Its Associated Bone Disease By Restoring the Perturbed Bone Homeostasis

Despite many therapeutic advances in recent years Multiple Myeloma (MM) still remains incurable in the majority of the patients. In addition, MM patients suffer significantly from co-morbidities including bone pain and renal insufficiency. Therefore, the development of novel treatments is warranted. The TAMR family consists of Tyro3, Axl and Mer which represent evolving targets in cancer. We demonstrated that the role of TAMR is non-redundant in hematologic malignancies, with Axl exerting an important function in AML, but not in MM, where Mer represents a novel target.Therefore, we tested the therapeutic potential of the Mer-inhibitor R992, which has an 8-fold selectivity over Tyro3 and a 13-fold selectivity over Axl in preclinical MM models (Rigel, San Francisco, USA).R992 exerted a dose-dependent growth inhibition of U266, JJN3 and RPMI8226 cells in vitro (n=3, *p
Source: Blood - Category: Hematology Authors: Tags: 652. Myeloma: Pathophysiology and Pre-Clinical Studies, excluding Therapy: Poster I Source Type: research

Related Links:

This study has suggested that the β-CD-GO could play an efficient and beneficial source of the adsorbent for the purpose of eliminating Cd(II) from aqueous solution.Graphical abstract
Source: Process Biochemistry - Category: Biochemistry Source Type: research
Publication date: April 2020Source: Biochemical Systematics and Ecology, Volume 89Author(s): Diego L. Lucca, Giovanna P. Sá, Leonardo R. Polastri, Denise M.B. Ghiraldi, Nagela P. Ferreira, Lucas U.R. Chiavelli, Ana L.T.G. Ruiz, Francielle P. Garcia, Jessica C. Paula, Celso V. Nakamura, Tania U. Nakamura, Brenda Kischkel, Debora B. Scariot, Dyenefer P. Fonseca, Silvana M.O. Santin, Maria A.M. Gutierre, Melyssa F.N. Negri, Armando M. PominiAbstractOrchidaceae are one of the largest families of flowering plants. In this work, the first phytochemical study of the non-flowering parts of the South American species Stanhop...
Source: Biochemical Systematics and Ecology - Category: Biochemistry Source Type: research
This article is protected by copyright. All rights reserved
Source: Biotechnology and Applied Biochemistry - Category: Biochemistry Authors: Tags: Original Article Source Type: research
Publication date: Available online 14 February 2020Source: Inorganica Chimica ActaAuthor(s): Aurel Tăbăcaru, Andreea Veronica Botezatu Dediu, Rodica Mihaela Dinică, Geta Cârâc, Vasile Basliu, Maria Paula Cabral Campello, Francisco Silva, Catarina I.G. Pinto, Joana F. Guerreiro, Marta Martins, Filipa Mendes, Fernanda MarquesAbstractA new mixed lanthanide(III) complex [LaNd(μ2-DPY)(μ4-SO4)2(Et3N)]Br2∙2H2O∙MeOH (La-Nd-DPY) was obtained by the reaction of N,N’-diphenacyl-4,4’-dipyridinium dibromide (DPB) with a mixture of La(III) and Nd(III) sulfates in a 2:1 molar ratio, in the presence of...
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
Publication date: 15 February 2020Source: New Scientist, Volume 245, Issue 3269Author(s): Michael Le PageFirst trial of this form of gene editing for people with tumours passes safety test
Source: New Scientist - Category: Science Source Type: research
Conclusion Predefined sex-specific bCT cut-off levels are helpful for the early detection of MTC and for predicting lateral neck lymph node metastasis.Ca-sCT did not improve preoperative diagnostics.bCT levels>43pg/ml and>100pg/ml for males and of>23pg/ml and>85pg/ml for females are relevant for advising patients and planning the extent of surgery. PMID: 32056502 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
Authors: Cesareo R, Pacella CM, Pasqualini V, Campagna G, Iozzino M, Gallo A, Lauria Pantano A, Cianni R, Pedone C, Pozzilli P, Taffon C, Crescenzi A, Manfrini S, Palermo A Abstract BACKGROUND: No direct prospective studies comparing laser ablation (LA) and radiofrequency ablation (RFA) for debulking benign non-functioning thyroid nodules (BNTNs) exist. We aimed to compare the efficacy and safety of both techniques in patients with solid or predominantly solid BNTN. METHODS: This six-month, single-use, randomized open label parallel trial compared the following primary endpoints between the RFA and LA groups si...
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
Publication date: 20 December 2019Source: Journal of Genetics and Genomics, Volume 46, Issue 12Author(s): Yang Duan, Xingyan Zhang, Lihong Yang, Xu Dong, Zhanye Zheng, Yiming Cheng, Hao Chen, Bei Lan, Dengwen Li, Jun Zhou, Chenghao Xuan
Source: Journal of Genetics and Genomics - Category: Genetics & Stem Cells Source Type: research
Authors: Bagan L, Jiménez Y, Leopoldo M, Murillo-Cortes J, Bagan J Abstract BACKGROUND: The main objective of our study was to identify oral symptoms and signs most likely to be associated with the exposure of necrotic bone in bisphosphonate-related osteonecrosis of the jaw (BRONJ). MATERIAL AND METHODS: The study group consisted of 183 patients with BRONJ. We recorded data on the underlying disease, bisphosphonate used, location of osteonecrosis, symptoms, pain, fistula development, suppuration, infection, exposed necrotic bone, and BRONJ stage. RESULTS: The mean age of the patients was 68.22 &plusm...
Source: Medicina Oral, Patologia Oral y Cirugia Bucal - Category: ENT & OMF Tags: Med Oral Patol Oral Cir Bucal Source Type: research
Skeletal metastases are an incurable complication afflicting the majority of patients who die from advanced breast cancer. They are most often osteolytic, characterized by net bone destruction and suppressed new bone formation. Life expectancy from first diagnosis of breast cancer bone metastases is several years, during which time skeletal-related events - including pain, fracture, hypercalcemia, and spinal cord compression - significantly degrade quality of life. The bone marrow niche can also confer hormonal and chemo-resistance. Most treatments for skeletal metastases target bone-destroying osteoclasts and are palliati...
Source: Breast Cancer Research - Category: Cancer & Oncology Authors: Source Type: research
More News: Cancer | Cancer & Oncology | Consultancies | Employment | Funding | Hematology | Myeloma | Oral Cancer | Orthopaedics | Osteoporosis | Pain | Study | Velcade