SF3B1 Mutations Associate with Low CD20 Expression in CLL: Another NOTCH1-Dependent Mechanism?

ConclusionsIn addition to NOTCH1-mut cases, also CLL cases bearing SF3B1 mutations are characterized by a lower CD20 expression, allegedly through a more active NOTCH1 pathway, potentially resulting in clinical resistance to anti-CD20 monoclonal antibodies.DisclosuresZaja: Amgen: Honoraria; Celgene: Honoraria, Research Funding; Novartis: Honoraria, Research Funding; Janssen: Honoraria; Takeda: Honoraria; Sandoz: Honoraria; Abbvie: Honoraria.

Source: Blood - November 21, 2018 Category: Hematology Authors: Pozzo, F., Bittolo, T., Tissino, E., Vit, F., Vendramini, E., Bomben, R., Zucchetto, A., Dal Bo, M., Laurenti, L., D'Arena, G. F., Di Raimondo, F., Chiarenza, A., Pozzato, G., Zaja, F., Del Poeta, G., Gattei, V. Tags: 641. CLL: Biology and Pathophysiology, excluding Therapy: Poster I Source Type: research