Checkpoint Blockade Therapy May Sensitize Hodgkin Lymphoma to Subsequent Therapy

Conclusions: In a heavily pretreated R/R HL population, treatment with CBT may sensitize patients to subsequent therapy, even after they progress on CBT. A response to CBT appears to correlate with response to post-CBT treatment, but PD to CBT did not preclude a response to subsequent therapy. Patient survival does not appear to be dependent upon the subsequent treatment regimen, although the majority of patients with at least stable disease went on to SCT. The long PFS in these patients is encouraging and may warrant further investigation. We plan to expand this analysis with additional patients prior to the December meeting.DisclosuresAdvani: Celgene: Research Funding; Roche/Genentech: Consultancy, Membership on an entity's Board of Directors or advisory committees, Other: Participated in an advisory board, Research Funding; Kyowa: Consultancy, Membership on an entity's Board of Directors or advisory committees, Other: Participated in an advisory board; Celgene: Research Funding; Astra Zeneca: Consultancy, Membership on an entity's Board of Directors or advisory committees, Other: Participated in an advisory board; Takeda: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Autolus: Membership on an entity's Board of Directors or advisory committees, Other: Participated in an advisory board; Millenium: Research Funding; Janssen: Research Funding; Regeneron: Research Funding; Bristol Myers Squibb: Membership on an entity's Board of Di...
Source: Blood - Category: Hematology Authors: Tags: 624. Hodgkin Lymphoma and T/NK Cell Lymphoma-Clinical Studies: Poster I Source Type: research