Preliminary Results of the Stapled Peptide ALRN-6924, a Dual Inhibitor of MDMX and MDM2, in Two Phase IIa Dose Expansion Cohorts in Relapsed/Refractory TP53 Wild-Type Peripheral T-Cell Lymphoma

Conclusion: ALRN-6924 has shown activity against PTCL and has an acceptable safety profile across QW and TIW dosing. The potential for pseudoprogression was not initially recognized, hence raising the possibility that the true response rate for QW may be higher. These early data support continued development of ALRN-6924 for the treatment of PTCL.DisclosuresShustov: Seattle Genetics: Research Funding. Horwitz: Celgene: Consultancy, Research Funding; Forty Seven: Consultancy, Research Funding; Infinity/Verastem: Consultancy, Research Funding; Seattle Genetics: Consultancy, Research Funding; Mundipharma: Consultancy; Kyowa-Hakka-Kirin: Consultancy, Research Funding; Spectrum: Research Funding; Millennium/Takeda: Consultancy, Research Funding; ADC Therapeutics: Consultancy, Research Funding; Portola: Consultancy; Aileron Therapeutics: Consultancy, Research Funding; Innate Pharma: Consultancy; Trillium: Consultancy; Corvus: Consultancy. Sokol: Seattle Genetics: Consultancy; Mallinckrodt Pharmaceuticals: Consultancy; Spectrum Pharmaceuticals: Consultancy. Meric-Bernstam: Genentech: Consultancy; Inflection Biosciences: Consultancy; Pieris Pharmaceuticals: Consultancy; Clearlight Diagnostics: Consultancy; Darwin Health: Consultancy; Bioepis: Consultancy; Novartis: Research Funding; AstraZeneca: Research Funding; Taiho Pharmaceuticals: Research Funding; Genentech: Research Funding; Calithera Biosciences: Research Funding; Debiopharm: Research Funding; Bayer: Research Funding; Aileron...
Source: Blood - Category: Hematology Authors: Tags: 624. Hodgkin Lymphoma and T/NK Cell Lymphoma-Clinical Studies: Poster I Source Type: research