A 36-Dimensional Cytometry by Time of Flight (CyTOF) Analysis of De Novo Acute Myeloid Leukemia (AML) Patients Eligible for Intensive Chemotherapy

ConclusionsBy applying unsupervised clustering analysis of over 40 de novo AML patients we identified leukemic cell subpopulations that had unique patterns of intracellular phospho-specific antibodies during start of induction therapy. Changes in intracellular markers during the first 24 hours of induction therapy could significantly be related to patient survival. By analyzing molecular alterations short time after chemotherapy, we aim to reveal the sub-clonal diversity and the heterogeneous responses to treatment. Identification of cancer cell subsets that are resistant to conventional chemotherapy may in the future be used to guide therapy in AML.DisclosuresGjertsen: Alden Cancer Therapy 2: Patents & Royalties: Alden Cancer Therapy II patent application in relation to CryoIT trial.; BerGenBio: Consultancy; Novartis: Consultancy; Alden Cancer Therapy 2: Membership on an entity's Board of Directors or advisory committees; Alden Cancer Therapy 2: Equity Ownership; Kinn Therapeutics: Membership on an entity's Board of Directors or advisory committees; Seattle Genetics: Consultancy; Kinn Therapeutics: Equity Ownership; Boehringer Ingelheim: Research Funding.
Source: Blood - Category: Hematology Authors: Tags: 617. Acute Myeloid Leukemia: Biology, Cytogenetics, and Molecular Markers in Diagnosis and Prognosis: Poster I Source Type: research