Application of Real-Time PCR for the Detection of BCR-ABL1-like Group in Pediatric Acute Lymphoblastic Leukemia Patients

Conclusion. Thus, we showed that described real-time PCR technology based on expression data of 5 genes allowed to detect the BCR-ABL1-like ALL patients with similar clinical characteristics, genetic parameters and treatment outcome to ones revealed by microarray, NGS or TLDA techniques. We believe that detection of BCR-ABL1-like profile by PCR can be used as fast and easy screening method in 'B-other' ALL for the further identification of tyrosine kinase fusion genes or other targetable lesions by NGS or FISH within this group only.DisclosuresNo relevant conflicts of interest to declare.

Source: Blood - November 21, 2018 Category: Hematology Authors: Tsaur, G., Muhacheva, T., Kovalev, S., Druy, A., Sibiryakov, P., Olshanskaya, Y., Soldatkina, O., Popov, A., Vlasova, A., Arakaev, O., Verzhbitskaya, T., Saveliev, L., Fechina, L. Tags: 612. Acute Lymphoblastic Leukemia: Clinical Studies: Poster I Source Type: research