Analysis of BRCA1 and BRCA2 Mutations and Gene Expression in Hematological Malignancies - Implications for Differential Involvement in Pathogenesis of Lymphoid Neoplasms

Conclusions: 1) The incidence of BRCA1/2 mut in patients with hematological malignancies is comparable to the frequency in a normal population. 2) Mut in JAK3 and POLD1 are significantly more frequent in cases with BRCA1/2 mut. 3) GE analyses revealed a strong DR of BRCA1 in CLL, T-PLL and MZL. 4) T-ALL and B-ALL were not found to show a BRCA1/2 DR. 5) DR correlates with a high mut frequency of ATM and JAK3, for BRCA2 also of BRAF and STAT5B. 6) Thus, not molecular mut in, but DR of BRCA1/2 in CLL, T-PLL and MZL could play a more important role in pathogenesis than so far expected.Figure.DisclosuresStengel: MLL Munich Leukemia Laboratory: Employment. Walter: MLL Munich Leukemia Laboratory: Employment. Hutter: MLL Munich Leukemia Laboratory: Employment. Kern: MLL Munich Leukemia Laboratory: Employment, Equity Ownership. Meggendorfer: MLL Munich Leukemia Laboratory: Employment. Haferlach: MLL Munich Leukemia Laboratory: Employment, Equity Ownership. Haferlach: MLL Munich Leukemia Laboratory: Employment, Equity Ownership.

Source: Blood - November 21, 2018 Category: Hematology Authors: Stengel, A., Walter, W., Hutter, S., Kern, W., Meggendorfer, M., Haferlach, T., Haferlach, C. Tags: 603. Oncogenes and Tumor Suppressors: Poster I Source Type: research