Cooperative Epigenetic Regulation By ASXL1 and NF1 Loss on Leukemogenesis

Conclusion: This study sheds lights on the understanding of the cooperative effect between epigenetic alterations and signaling pathways in accelerating the progression of myeloid malignancies and provides a rationale therapeutic strategy for the treatment of myeloid malignancies with ASXL1 and RAS pathway gene mutations.DisclosuresNo relevant conflicts of interest to declare.

Source: Blood - November 21, 2018 Category: Hematology Authors: Zhang, P., He, F., Bai, J., Chen, S., Nimer, S. D., Zhou, Y., Xu, M., Wang, Q., Yang, F.-C. Tags: 602. Disordered Gene Expression in Hematologic Malignancy, including Disordered Epigenetic Regulation: Epigenetic Modification Source Type: research