Results from REACH1, a Single-Arm Phase 2 Study of Ruxolitinib in Combination with Corticosteroids for the Treatment of Steroid-Refractory Acute Graft-Vs-Host Disease

Introduction:Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative treatment option for patients with high-risk or relapsed hematologic malignancies. Development of acute graft-vs-host disease (aGVHD) is a risk factor for nonrelapse mortality after allo-HSCT. Systemic corticosteroids (CS) are recommended first-line treatment for aGVHD, but
Source: Blood - Category: Hematology Authors: Tags: 722. Clinical Allogeneic Transplantation: Acute and Chronic GVHD, Immune Reconstitution: GVHD Treatment and Prevention Strategies Source Type: research

Related Links:

Conclusion: The incidence of major complications was low which only occurred in SHPT patients. Most of the patients with complications recovered spontaneously. MWA is safe for the treatment of HPT. PMID: 31818158 [PubMed - in process]
Source: International Journal of Hyperthermia - Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research
Is sildenafil a safe and effective treatment option for preeclampsia in pregnancy? A new review examines the evidence.Nephrology Dialysis Transplantation
Source: Medscape Radiology Headlines - Category: Radiology Tags: Ob/Gyn & Women ' s Health Journal Article Source Type: news
Authors: Peris A, Girardi E, Bombardi M, Seghieri G PMID: 31820873 [PubMed - as supplied by publisher]
Source: Minerva Anestesiologica - Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
Publication date: Available online 10 December 2019Source: The LancetAuthor(s): Maria-Victoria Mateos, Michele Cavo, Joan Blade, Meletios A Dimopoulos, Kenshi Suzuki, Andrzej Jakubowiak, Stefan Knop, Chantal Doyen, Paulo Lucio, Zsolt Nagy, Ludek Pour, Mark Cook, Sebastian Grosicki, Andre Crepaldi, Anna Marina Liberati, Philip Campbell, Tatiana Shelekhova, Sung-Soo Yoon, Genadi Iosava, Tomoaki FujisakiSummaryBackgroundStandard-of-care treatment for patients with newly diagnosed multiple myeloma includes combination therapies for patients who are not eligible for autologous stem-cell transplantation. At the primary analysis ...
Source: The Lancet - Category: General Medicine Source Type: research
Publication date: Available online 11 December 2019Source: Best Practice &Research Clinical Endocrinology &MetabolismAuthor(s): Edith Lahner, Laura Conti, Francesco Cicone, Silvia Capriello, Maria Cazzato, Marco Centanni, Bruno Annibale, Camilla ViriliAbstractThe association between autoimmune atrophic gastritis and thyroid disorders has been observed since the early 1960s and the expression “thyrogastric syndrome” was coined to indicate the presence of thyroid autoantibodies or autoimmune thyroid disease in patients with pernicious anemia, a late clinical stage of autoimmune atrophic gastritis. More re...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - Category: Endocrinology Source Type: research
Publication date: Available online 11 December 2019Source: Pharmacology &TherapeuticsAuthor(s): Yinglu Guan, Guan Wang, Danielle Fails, Priyadharsini Nagarajan, Yejing GeAbstractCancer hijacks embryonic development and adult wound repair mechanisms to fuel malignancy. Cancer frequently originates from de-regulated adult stem cells or progenitors, which are otherwise essential units for postnatal tissue remodeling and repair. Cancer genomics studies have revealed convergence of multiple cancers across organ sites, including squamous cell carcinomas (SCCs), a common group of cancers arising from the head and neck, esopha...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
ConclusionsCurcumin improved insulin resistance, lipid profile and systemic inflammation by reducing HOMA-IR, TG, TG/HDL ratio and hs-CRP levels in β-thalassemia major patients. Curcumin may be useful as an adjuvant therapy for attenuation of the metabolic complications in these patients.
Source: Journal of Herbal Medicine - Category: Complementary Medicine Source Type: research
In this study, we found that ozone-gas-mediated removal of hydrocarbon contaminants and introduction of –OH groups significantly increased the surface hydrophilicity of acid-etched Ti without changing the original surface topography. Ozone-gas-treated Ti dramatically enhanced osteogenic differentiation of mesenchymal stem cells, as evidenced by greater cell proliferation, alkaline phosphatase activity, and bone-like nodule formation compared with original Ti.Graphical abstract
Source: Materials Letters - Category: Materials Science Source Type: research
Authors: Su R, Li Z, Wang Y, Liu Y, Zheng X, Gao C, Li X, Wang C Abstract OBJECTIVES: Infection is one of the leading causes of morbidity and mortality in patients with systemic lupus erythematosus (SLE). Excessive use of glucocorticoids, disease-modifying anti-rheumatic drugs (DMARDs) and immune disturbances associated with lupus itself lead to reduced immune function with consequent increases in opportunistic infections, such as Epstein-Barr virus (EBV) and cytomegalovirus (CMV). A recent study showed that an imbalance between T helper 17 (Th17) cells and regulatory T (Treg) cells is a major cause of autoimmune d...
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
More News: Acute Leukemia | Acute Myeloid Leukemia | Anemia | Cancer & Oncology | Chronic Leukemia | Clinical Trials | Corticosteroid Therapy | Cytomegalovirus | Employment | Gastroenterology | Hematology | Leukemia | Merck | Myelodysplastic Syndrome | Skin | Skin Graft | Stem Cell Therapy | Stem Cells | Study | Transplants