Frequent STAT3 Mutations in CD8+ T Cells from Patients with Pure Red Cell Aplasia

Conclusion: STAT3 mutations are frequently detected in the CD8+ T cells of PRCA patients, regardless of the presence of T-LGLL. The identification of STAT3 mutations may be useful for appropriately managing patients with PRCA.Figure.DisclosuresNakao: Novartis: Honoraria; Kyowa Hakko Kirin Co., Ltd.: Honoraria; Alexion Pharmaceuticals, Inc.: Consultancy, Honoraria.

Source: Blood - November 21, 2018 Category: Hematology Authors: Kawakami, T., Sekiguchi, N., Kobayashi, J., Imi, T., Matsuda, K., Yamane, T., Nishina, S., Senoo, Y., Sakai, H., Ito, T., Koizumi, T., Hirokawa, M., Nakao, S., Nakazawa, H., Ishida, F. Tags: 508. Bone Marrow Failure: Acquired Bone Marrow Failure and Somatic Genetics Source Type: research