NOAC Therapy Is Also Effective and Safe in Patients Older Than 80 Years -- Results of the Prospective Dresden NOAC Registry (NCT01588119)

Conclusions: During long-term FU of more than 2.5 years, this very old population of NOAC recipients demonstrated low rates of cardiovascular or major bleeding complications during active NOAC therapy. Approximately one quarter of the study population died during follow-up, with cardiovascular events being the leading cause of death. Only 11 fatal bleeding events were observed; however, most of the 58 fatal thromboembolic events occurred after anticoagulation was discontinued. This indicates that continued anticoagulation with NOACs may result in a beneficial risk-benefit ratio also in very old patients.DisclosuresBeyer-Westendorf: Bayer: Honoraria, Research Funding; Boehringer-Ingelheim: Honoraria, Research Funding; Pfizer: Honoraria, Research Funding; Daiichi Sankyo: Honoraria, Research Funding. Marten: Bayer: Honoraria; Daiichi Sankyo: Honoraria.
Source: Blood - Category: Hematology Authors: Tags: 332. Antithrombotic Therapy: Management of Challenging Patients and Scenarios Source Type: research

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Publication date: May 2020Source: Epilepsy &Behavior, Volume 106Author(s): Laura Abraira, Nicola Giannini, Estevo Santamarina, Sonia Cazorla, Alejandro Bustamante, Manuel Quintana, Manuel Toledo, Laia Grau-López, Marta Jiménez, Jordi Ciurans, Juan Luis Becerra, Mónica Millán, Pere Cardona, Mikel Terceño, Josep Zaragoza, David Cánovas, Teresa Gasull, Xavier Ustrell, Marta Rubiera, Mar Castellanos
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Publication date: Available online 2 April 2020Source: Brain StimulationAuthor(s): Qi Wang, Dai Zhang, Ying-Yu Zhao, Hong Hai, Yue-Wen Ma
Source: Brain Stimulation - Category: Neurology Source Type: research
Authors: Alcázar-Leyva S, Zapata E, Bernal-Alcántara D, Gorocica P, Alvarado-Vásquez N Abstract Although thiamine pyrophosphate (TPP) is considered a protective agent for endothelial cells, it is still unknown if this is associated with nitric oxide (NO) synthesis. Our aim was to evaluate the synthesis of NO in endothelial cells incubated with TPP and high glucose concentrations. Endothelial cells from the umbilical cord vein from newborns (n = 20), were incubated with 5, 15 or 30 mmol/L glucose, in absence or presence of 0.625 mg/ml of TPP. Our results showed a significant...
Source: International Journal for Vitamin and Nutrition Research - Category: Nutrition Tags: Int J Vitam Nutr Res Source Type: research
CONCLUSION: The timing of treatment for gallstone disease is an essential determinant of therapeutic success. PMID: 32234195 [PubMed - in process]
Source: Deutsches Arzteblatt International - Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research
CONCLUSION: Current data imply that PCI for CCS does not improve outcomes in a large percentage of cases. A symptomatic benefit exists only in patients with frequent angina pectoris. The selection of CCS patients for PCI needs to be more strictly bound to the recommendations of current guidelines, particularly in Germany. PMID: 32234189 [PubMed - in process]
Source: Deutsches Arzteblatt International - Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research
Smartphone apps using PPG signals to diagnose atrial fibrillation accurately identified patients with the condition, but researchers have concerns about the level of false positives produced by them.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news
Adding clopidogrel added no efficacy but caused additional bleeding episodes.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Cardiology News Source Type: news
We report the case of a 58 year old man with occult obscure gastro-intestinal bleeding (OGIB) without other significant symptoms, in which systemic localisation of follicular B-cell non-Hodgkin lymphoma was discovered trough capsule endoscopy. This case reflects the clinical significance of performing capsule endoscopy in patients with OGIB. PMID: 32233275 [PubMed - in process]
Source: Acta Gastro-Enterologica Belgica - Category: Gastroenterology Tags: Acta Gastroenterol Belg Source Type: research
Conclusion: Both EVL and CI are almost as effective in achieving endoscopic hemostasis. CI is more effective, feasible, and could be used as a salvage therapy and/or spared for risky active bleeding esophageal varices. PMID: 32233265 [PubMed - in process]
Source: Acta Gastro-Enterologica Belgica - Category: Gastroenterology Tags: Acta Gastroenterol Belg Source Type: research
This study included 1962 patients who underwent transesophageal echocardiographic examination (TEE) prior to cardioversion or ablation in the years 2014-2018 in three cardiac centers. RESULTS: More than a quarter of AF patients had decreased eGFR (
Source: Cardiology Journal - Category: Cardiology Authors: Tags: Cardiol J Source Type: research
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