Does Provider Experience Treating Patients (pts) with Myelodysplastic Syndromes (MDS) Explain Duration of Hypomethylating Agent (HMA) Therapy and Overall Survival (OS)? A Large Population-Based Analysis

Conclusions: MDS pts whose providers were more experienced with HMA had higher odds of receiving persistent HMA than pts with less experienced providers. However, there was no difference in the OS based on provider experience. These findings suggest specialized care of MDS pts can decrease inappropriate early discontinuation of HMA therapy, but does not seem to improve OS. Further research into the underlying reasons for the gap in OS between HMA-treated pts observed in clinical trials compared to real-life setting is warranted to help develop interventions to improve outcomes at the population setting.DisclosuresZeidan: Celgene: Consultancy; Pfizer: Consultancy; Novartis: Consultancy; Incyte: Employment; Gilead: Consultancy; Abbvie: Consultancy; Agios: Consultancy; Ariad: Consultancy, Speakers Bureau. Huntington: Bayer: Consultancy; Celgene: Consultancy; Janssen: Consultancy. Podoltsev: Celator: Research Funding; Astellas Pharma: Research Funding; Boehringer Ingelheim: Research Funding; Daiichi Snakyo: Research Funding; Pfizer: Membership on an entity's Board of Directors or advisory committees; Genentech: Research Funding; Astex Pharmaceuticals: Research Funding; Celgene: Research Funding; Sunesis Pharmaceuticals: Research Funding; Pfizer: Research Funding; LAM Therapeutics: Research Funding. Gore: Celgene: Consultancy, Research Funding. Ma: Incyte: Consultancy; Celgene: Consultancy. Davidoff: Celgene: Research Funding.
Source: Blood - Category: Hematology Authors: Tags: 904. Outcomes Research-Malignant Conditions: Outcomes in Myeloid Malignancies and Allogeneic Stem Cell Transplant Source Type: research