Conditional Survival and Mortality Risks after Allogeneic Hematopoietic Cell Transplantation (alloHCT) in Patients Who Survived Varying Length of Time after Allohct

Conclusions: The projected 5-y survival rates improve conditional on time survived from alloHCT; 5-y survival is nearly 90% for those who have already survived 5y. However, alloHCT recipients who have survived 10+y continue to remain at increased risk of death compared to the general population, with SMN as the most common cause. Acute GvHD is associated with decreased risk of DRM as expected, whereas acute GvHD and TBI are associated with increased risk of NDRM. DRM and GvHD-related mortality rates decline with survival time, while among ≥5y survivors, NDRM exceeds DRM. Conditional survival and mortality estimates provide clinically relevant prognostic information, helping to inform preventive and interventional strategies.DisclosuresForman: Mustang Therapeutics: Other: Licensing Agreement, Patents & Royalties, Research Funding.

Source: Blood - November 21, 2018 Category: Hematology Authors: Wong, F. L., Xiao, M., Berano Teh, J., Atencio, L., Gonzales, A., Hinton, A., Iukuridze, D., Forman, S. J., Nakamura, R., Armenian, S. H. Tags: 904. Outcomes Research-Malignant Conditions: Outcomes in Myeloid Malignancies and Allogeneic Stem Cell Transplant Source Type: research