Pre-Transplant and Peri-d100 Gastrointestinal Dysbiosis Is Associated with the Subsequent Development of Chronic Graft-Versus-Host Disease

ConclusionHere, we report for the first time, genus-level intestinal microbial signatures that are associated with cGVHD, identifiable at pre-transplant (Prevotella) and peri-d100 (Akkermansia, Streptococcus) time points, prior to cGVHD onset. Interestingly, at species level, Prevotella copri abundance has been mechanistically associated with new-onset rheumatoid arthritis, and we have previously associated Akkermansia muciniphilia, a commensal bacteria with known mucus-degrading capacity, with aGVHD in pre-clinical studies. Thus, the cGVHD-associated dysbiosis we have identified may have value as both a biomarker for cGVHD risk and mechanistic relevance.Figure 1.DisclosuresPerales: Merck: Other: Personal fees; Takeda: Other: Personal fees; Novartis: Other: Personal fees; Abbvie: Other: Personal fees; Incyte: Membership on an entity's Board of Directors or advisory committees, Other: Personal fees and Clinical trial support. Peled: Seres Therapeutics: Research Funding.

Source: Blood - November 21, 2018 Category: Hematology Authors: Markey, K. A., Gomes, A. L., Littmann, E. R., Devlin, S. M., Slingerland, A. E., Slingerland, J. B., Clurman, A., Moore, G., Fatmi, S. A., Maloy, M., Pamer, E. G., Taur, Y., Giralt, S., Perales, M.-A., Ponce, D., Peled, J. U., van den Brink, M. R. M. Tags: 722. Clinical Allogeneic Transplantation: Acute and Chronic GVHD, Immune Reconstitution: Biomarkers and the Microbiome Source Type: research