Predictors of Response in Patients Receiving CD34-Selected Stem Cell Infusions without Conditioning to Correct Graft Failure Following Allogeneic Stem Cell Transplantation
Conclusions: This analysis represents the largest report of outcomes in patients who have received a CD34+ selected stem cell infusion without conditioning for GF. Negative donor/recipient CMV serostatus and sex matching predicted response. In responding patients, GF initially affecting <3 lineages was a predictor of better OS at 5 years. New strategies including cytokine or agonist support, or second transplant need to be investigated in partially or non-responding patients.DisclosuresHough: University College London Hospital's NHS Foundation Trust: Employment.
Source: Blood - Category: Hematology Authors: Cuadrado, M. d. M., Lowdell, M. W., Ings, S., Watts, M. J., Szydlo, R., Anthias, C., Madrigal, J. A., Kottaridis, P., Carpenter, B., Hough, R., Peggs, K., Thomson, K., Morris, E., Chakraverty, R. Tags: 721. Clinical Allogeneic Transplantation: Conditioning Regimens, Engraftment, and Acute Transplant Toxicities: Comorbidity and Novel Strategies to Improve Graft Function Source Type: research
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