Weighty Choices: Selecting Optimal G-CSF Doses for Stem Cell Mobilization to Optimize Yield
Conclusions. Our data indicates a correlation between average daily G-CSF dose and CD34+ cell yield in normal and overweight donors. However, in obese and morbidly obese donors, there was no benefit in CD34+ yield with increasing average daily G-CSF dose above 780 mcg and 900 mcg respectively. Therefore, there appears to be a maximum effective G-CSF dose for mobilization in obese and morbidly obese donors where higher doses of G-CSF add no additional benefit and may result in additional complications.DisclosuresPulsipher: Novartis: Consultancy, Honoraria, Speakers Bureau; Amgen: Honoraria; Adaptive Biotech: Consultancy, Research Funding; CSL Behring: Consultancy.
Source: Blood - Category: Hematology Authors: Farhadfar, N., Hsu, J. W., Logan, B. R., Sees, J. A., Chitphakdithai, P., Confer, D. L., Pulsipher, M. A., Shah, N. N., Switzer, G. E., Shaw, B. E., Wingard, J. R. Tags: 711. Cell Collection and Processing II Source Type: research
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