Greater Barriers to Hydroxyurea (HU) Associated with Poorer Health Related Quality of Life (HRQL) in Youth with Sickle Cell Disease

Conclusions: HU barriers were frequently reported but differed by parent versus youth perspective. To improve HU adherence in youth with SCD, barriers of both dyad members must be addressed. Greater barriers were associated with poorer total generic and disease-specific HRQL. Controlling for group assignment and time, CHW support helped youth to address HU ingestion barriers. The relationships between perceived barriers, HU adherence and HRQL are complex. Perceived HU barriers may mediate the relationship between an intervention to improve adherence and HRQL. A multi-site trial powered to test these relationships is underway.References1Green et al. (2017) Pediatr Blood Cancer, 64; e26689.https://doi.org/10.1002/pbc.266892Smaldone et al. (2018) J Pediatr; 197:177-185.3Simon, LE, Blount, RL. (2007) J Pediatr Psychol; 32:831-844.4Oyeku et al. (2013) Pediatr Blood Cancer; 60:653-658.5Panepinto et al. (2013) Pediatr Blood Cancer, 60:1338-44.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - Category: Hematology Authors: Tags: 903. Outcomes Research-Non-Malignant Hematology: Health Outcomes in Sickle Cell Disease and Mucopolysaccharidosis Source Type: research