Fecal microbiota transplantation shortens the colonization period and allows the re-entry of patients carrying carbapenamase-producing bacteria into medical care facilities

Since the first description of a plasmidic Enterobacteriaceae carbapenemase, Klebsiella pneumoniae carbapenemase (KPC) in the USA [1], a wide variety of plasmid-borne resistance mechanisms have been described, mainly through metalloenzymes such as, New Delhi Metallo-beta-lactamase (NDM), or oxacillinases type OXA-48-like carbapenemases. Current epidemiology of carbapenemase-producing Enterobacteriacae (CPE) shows a global dissemination with endemic distributions and outbreaks, leading to public health concerns [2,3].

Source: International Journal of Antimicrobial Agents - November 22, 2018 Category: Drugs & Pharmacology Authors: Nadia SA ÏDANI, Jean-Christophe LAGIER, Nadim CASSIR, Matthieu MILLION, Sophie BARON, Grégory DUBOURG, Carole ELDIN, Jad KERBAJ, Camille VALLES, Didier RAOULT, Philippe BROUQUI Source Type: research