Unique mode of binding between angiotensin II type 1 receptor and its blockers.

CONCLUSIONS: The interaction between 5-oxo-1,2,4-oxadiazole in AZL and Arg167 in the AT1R appears to be more important than the interaction between the tetrazole ring in CAN and Arg167.
PMID: 30453795 [PubMed - as supplied by publisher]

Source: Clinical and Experimental Hypertension - November 19, 2018 Category: Cardiology Authors: Matsuo Y, Suematsu Y, Tomita S, Tashiro K, Kuwano T, Kitajima K, Miura SI Tags: Clin Exp Hypertens Source Type: research